FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383268283> ?p ?o ?g. }

• W4383268283 endingPage "117" @default.
• W4383268283 startingPage "97" @default.
• W4383268283 abstract "The field of cardiovascular regenerative medicine continues to evolve with the hope of discovering effective and durable treatments for patients suffering from heart disease. Human trials testing “first generation” cell therapy candidates, including bone marrow-derived cells, demonstrated a favorable safety profile with mixed efficacy results. While the cardiomyogenic, and hence, remuscularization potential of bone marrow cells has been refuted, select bone marrow cell populations have been linked to paracrine-mediated anti-inflammatory, angiogenic, immunomodulatory, and other cardioprotective effects. With this understanding, human trials are now exploring the therapeutic potential of these therapies in select patient populations who are more likely to respond, thus ushering in a new era of personalized regenerative medicine. In parallel, a new generation of potentially therapeutic cardiomyocytes, cardiac progenitor cells, cardiac fibroblasts, and endothelial cells derived from genetically and conditionally reprogrammed induced pluripotent stem cell (iPSC) sources using well-defined differentiation protocols has emerged. While these “heart cells” are well characterized and can be efficiently derived from iPSCs in vitro, there is still little compelling evidence that transplanting these cells into the injured myocardium improves functional and disease-modifying responses in vivo. Immune clearance, lack of significant engraftment of transplanted cells to host cardiomyocytes, and inefficient delivery approaches may be implicated in these initial results. Derivatives of heart cells from iPSC sources such as extracellular matrix, exosomes, microRNAs, proteins, and nucleotides in isolation and combination with progenitor cells are also being investigated for potential future clinical cardiac applications. This chapter will review critical descriptions of cardiomyocytes, cardiac progenitor cells, cardiac fibroblasts, and endothelial cells from iPSC sources, their derivatives, and efforts directed toward cardio-therapeutic applications." @default.
• W4383268283 created "2023-07-06" @default.
• W4383268283 creator A5034479866 @default.
• W4383268283 creator A5068190014 @default.
• W4383268283 creator A5082616445 @default.
• W4383268283 date "2023-01-01" @default.
• W4383268283 modified "2023-09-24" @default.
• W4383268283 title "“Heart Cells” Derived from Pluripotent Stem Cells and Therapeutic Applications" @default.
• W4383268283 cites W1597673292 @default.
• W4383268283 cites W1808455042 @default.
• W4383268283 cites W1889746212 @default.
• W4383268283 cites W1966563415 @default.
• W4383268283 cites W1967011376 @default.
• W4383268283 cites W1970288681 @default.
• W4383268283 cites W1970895128 @default.
• W4383268283 cites W1970947849 @default.
• W4383268283 cites W1977025496 @default.
• W4383268283 cites W1982815250 @default.
• W4383268283 cites W1987506766 @default.
• W4383268283 cites W1990973053 @default.
• W4383268283 cites W1994232607 @default.
• W4383268283 cites W1995527023 @default.
• W4383268283 cites W2005066007 @default.
• W4383268283 cites W2006557127 @default.
• W4383268283 cites W2006562250 @default.
• W4383268283 cites W2006743934 @default.
• W4383268283 cites W2008502472 @default.
• W4383268283 cites W2010417854 @default.
• W4383268283 cites W2011311188 @default.
• W4383268283 cites W2015538847 @default.
• W4383268283 cites W2016165259 @default.
• W4383268283 cites W2016576487 @default.
• W4383268283 cites W2022783910 @default.
• W4383268283 cites W2025120360 @default.
• W4383268283 cites W2026268864 @default.
• W4383268283 cites W2026749151 @default.
• W4383268283 cites W2031203524 @default.
• W4383268283 cites W2034276856 @default.
• W4383268283 cites W2038543378 @default.
• W4383268283 cites W2044697199 @default.
• W4383268283 cites W2045560703 @default.
• W4383268283 cites W2046253273 @default.
• W4383268283 cites W2051521659 @default.
• W4383268283 cites W2055023662 @default.
• W4383268283 cites W2061991201 @default.
• W4383268283 cites W2064632433 @default.
• W4383268283 cites W2065171831 @default.
• W4383268283 cites W2065931840 @default.
• W4383268283 cites W2066390373 @default.
• W4383268283 cites W2069940803 @default.
• W4383268283 cites W2072990456 @default.
• W4383268283 cites W2074420452 @default.
• W4383268283 cites W2074431288 @default.
• W4383268283 cites W2075401648 @default.
• W4383268283 cites W2075469935 @default.
• W4383268283 cites W2079006323 @default.
• W4383268283 cites W2079697285 @default.
• W4383268283 cites W2080539468 @default.
• W4383268283 cites W2082714048 @default.
• W4383268283 cites W2083166838 @default.
• W4383268283 cites W2083599207 @default.
• W4383268283 cites W2086294280 @default.
• W4383268283 cites W2086876030 @default.
• W4383268283 cites W2086943348 @default.
• W4383268283 cites W2091099944 @default.
• W4383268283 cites W2093478847 @default.
• W4383268283 cites W2093494581 @default.
• W4383268283 cites W2095751099 @default.
• W4383268283 cites W2096076159 @default.
• W4383268283 cites W2099697301 @default.
• W4383268283 cites W2101840264 @default.
• W4383268283 cites W2101986300 @default.
• W4383268283 cites W2104206289 @default.
• W4383268283 cites W2106111979 @default.
• W4383268283 cites W2106326450 @default.
• W4383268283 cites W2110275759 @default.
• W4383268283 cites W2118221757 @default.
• W4383268283 cites W2125987139 @default.
• W4383268283 cites W2126874122 @default.
• W4383268283 cites W2129460482 @default.
• W4383268283 cites W2130308734 @default.
• W4383268283 cites W2132735690 @default.
• W4383268283 cites W2134695487 @default.
• W4383268283 cites W2135241125 @default.
• W4383268283 cites W2138977668 @default.
• W4383268283 cites W2142046859 @default.
• W4383268283 cites W2143229579 @default.
• W4383268283 cites W2144327104 @default.
• W4383268283 cites W2153667577 @default.
• W4383268283 cites W2156140279 @default.
• W4383268283 cites W2158128644 @default.
• W4383268283 cites W2166305181 @default.
• W4383268283 cites W2166752078 @default.
• W4383268283 cites W2169859308 @default.
• W4383268283 cites W2196490965 @default.
• W4383268283 cites W2254879660 @default.
• W4383268283 cites W2302839786 @default.
• W4383268283 cites W2346955045 @default.

• next