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• W4383301537 endingPage "8574" @default.
• W4383301537 startingPage "8563" @default.
• W4383301537 abstract "Abstract Hel308 helicases promote genome stability in archaea and are conserved in metazoans, where they are known as HELQ. Their helicase mechanism is well characterised, but it is unclear how they specifically contribute to genome stability in archaea. We show here that a highly conserved motif of Hel308/HELQ helicases (motif IVa, F/YHHAGL) modulates both DNA unwinding and a newly identified strand annealing function of archaeal Hel308. A single amino acid substitution in motif IVa results in hyper-active DNA helicase and annealase activities of purified Hel308 in vitro. All-atom molecular dynamics simulations using Hel308 crystal structures provided a molecular basis for these differences between mutant and wild type Hel308. In archaeal cells, the same mutation results in 160000-fold increased recombination, exclusively as gene conversion (non-crossover) events. However, crossover recombination is unaffected by the motif IVa mutation, as is cell viability or DNA damage sensitivity. By contrast, cells lacking Hel308 show impaired growth, increased sensitivity to DNA cross-linking agents, and only moderately increased recombination. Our data reveal that archaeal Hel308 suppresses recombination and promotes DNA repair, and that motif IVa in the RecA2 domain acts as a catalytic switch to modulate the separable recombination and repair activities of Hel308." @default.
• W4383301537 created "2023-07-07" @default.
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• W4383301537 date "2023-07-06" @default.
• W4383301537 modified "2023-09-26" @default.
• W4383301537 title "Archaeal Hel308 suppresses recombination through a catalytic switch that controls DNA annealing" @default.
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• W4383301537 doi "https://doi.org/10.1093/nar/gkad572" @default.
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• W4383301537 hasPublicationYear "2023" @default.
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