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- W4383301945 abstract "黑色素瘤恶性程度高，发病机制复杂。细胞周期蛋白D1（cyclin D1）和细胞周期蛋白依赖性激酶4（cyclin-dependent kinases 4，CDK4）是细胞周期进程中的重要分子，可形成复合物发挥功能促进细胞从G1期进入S期。cyclin D1和CDK4的异常在黑色素瘤，尤其是肢端黑色素瘤中常见，与黑色素瘤的发生关系密切。cyclin D1在黑色素瘤中的异常主要表现为其编码基因CCND1扩增和蛋白表达升高。CDK4在黑色素瘤中的异常可表现为基因扩增或点突变。了解cyclin D1和CDK4在黑色素瘤中的异常，有助于良恶性黑色素细胞肿瘤的鉴别诊断，也可为CDK4抑制剂在黑色素瘤治疗中的作用提供参考，并可能有助于靶向治疗患者的筛选。." @default.
- W4383301945 created "2023-07-07" @default.
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- W4383301945 date "2023-07-08" @default.
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- W4383301945 title "[Advance on cyclin D1 and CDK4 in cutaneous melanoma]." @default.
- W4383301945 doi "https://doi.org/10.3760/cma.j.cn112151-20221230-01090" @default.
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