Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383301992> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W4383301992 abstract "Approximately 10-20% of patients with gastroesophageal adenocarcinoma (GE-ADK) have HER2-positive tumors. The addition of trastuzumab to chemotherapy improves OS in patients with advanced disease. We investigated the effect of perioperative trastuzumab on survival outcomes.This French, multicenter, retrospective observational study included HER2-positive GE-ADK patients treated between January 2015 and December 2020. The primary endpoint was DFS at 18 months. Secondary endpoints were pathological complete response rate (pCR), R0 resection rate, OS, and toxicity.Forty-eight patients were included, and they received a median of 6 cycles of preoperative treatment, with grade III/IV adverse events occurring in 23%. Pathologic complete response (pCR) and major pCR according to Mandard system were achieved in 5/48 (10%) and 20/48 (42%) patients, respectively. Loss of HER2 expression was observed in 18/48 (38%) patients. Postoperative complications rate according to the Clavien Dindo classification (≥3) was 37.5%. After a median follow-up of 29 months, the 18-month DFS was 80.4% (95% CI 68.9-93.8) and the 2-year OS rate was 89.0%. Subgroup analysis showed a longer DFS for gastric tumor than gastro-esophageal junction tumor.This study suggests that perioperative chemotherapy with trastuzumab in patients with HER2-positive GE-ADK is feasible and safe with encouraging survival." @default.
- W4383301992 created "2023-07-07" @default.
- W4383301992 creator A5013804257 @default.
- W4383301992 creator A5014967767 @default.
- W4383301992 creator A5026596818 @default.
- W4383301992 creator A5033663279 @default.
- W4383301992 creator A5040360907 @default.
- W4383301992 creator A5040688022 @default.
- W4383301992 creator A5050101046 @default.
- W4383301992 creator A5061710022 @default.
- W4383301992 creator A5083396561 @default.
- W4383301992 date "2023-07-01" @default.
- W4383301992 modified "2023-09-23" @default.
- W4383301992 title "Addition of trastuzumab to perioperative chemotherapy in HER2-positive gastroesophageal adenocarcinoma patients: A multicenter retrospective observational AGEO study" @default.
- W4383301992 cites W1977468182 @default.
- W4383301992 cites W2024177665 @default.
- W4383301992 cites W2096998881 @default.
- W4383301992 cites W2115072149 @default.
- W4383301992 cites W2133105825 @default.
- W4383301992 cites W2137086207 @default.
- W4383301992 cites W2140927379 @default.
- W4383301992 cites W2146834306 @default.
- W4383301992 cites W2151570682 @default.
- W4383301992 cites W2152121934 @default.
- W4383301992 cites W2598633947 @default.
- W4383301992 cites W2790743103 @default.
- W4383301992 cites W2892163061 @default.
- W4383301992 cites W2898867204 @default.
- W4383301992 cites W2947165559 @default.
- W4383301992 cites W3033366394 @default.
- W4383301992 cites W3160746523 @default.
- W4383301992 cites W4200595129 @default.
- W4383301992 cites W4226156918 @default.
- W4383301992 cites W4283014372 @default.
- W4383301992 doi "https://doi.org/10.1016/j.dld.2023.06.007" @default.
- W4383301992 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37407316" @default.
- W4383301992 hasPublicationYear "2023" @default.
- W4383301992 type Work @default.
- W4383301992 citedByCount "0" @default.
- W4383301992 crossrefType "journal-article" @default.
- W4383301992 hasAuthorship W4383301992A5013804257 @default.
- W4383301992 hasAuthorship W4383301992A5014967767 @default.
- W4383301992 hasAuthorship W4383301992A5026596818 @default.
- W4383301992 hasAuthorship W4383301992A5033663279 @default.
- W4383301992 hasAuthorship W4383301992A5040360907 @default.
- W4383301992 hasAuthorship W4383301992A5040688022 @default.
- W4383301992 hasAuthorship W4383301992A5050101046 @default.
- W4383301992 hasAuthorship W4383301992A5061710022 @default.
- W4383301992 hasAuthorship W4383301992A5083396561 @default.
- W4383301992 hasConcept C121608353 @default.
- W4383301992 hasConcept C126322002 @default.
- W4383301992 hasConcept C141071460 @default.
- W4383301992 hasConcept C143998085 @default.
- W4383301992 hasConcept C167135981 @default.
- W4383301992 hasConcept C203092338 @default.
- W4383301992 hasConcept C2776694085 @default.
- W4383301992 hasConcept C2779786085 @default.
- W4383301992 hasConcept C2781182431 @default.
- W4383301992 hasConcept C31174226 @default.
- W4383301992 hasConcept C530470458 @default.
- W4383301992 hasConcept C535046627 @default.
- W4383301992 hasConcept C71924100 @default.
- W4383301992 hasConcept C90924648 @default.
- W4383301992 hasConceptScore W4383301992C121608353 @default.
- W4383301992 hasConceptScore W4383301992C126322002 @default.
- W4383301992 hasConceptScore W4383301992C141071460 @default.
- W4383301992 hasConceptScore W4383301992C143998085 @default.
- W4383301992 hasConceptScore W4383301992C167135981 @default.
- W4383301992 hasConceptScore W4383301992C203092338 @default.
- W4383301992 hasConceptScore W4383301992C2776694085 @default.
- W4383301992 hasConceptScore W4383301992C2779786085 @default.
- W4383301992 hasConceptScore W4383301992C2781182431 @default.
- W4383301992 hasConceptScore W4383301992C31174226 @default.
- W4383301992 hasConceptScore W4383301992C530470458 @default.
- W4383301992 hasConceptScore W4383301992C535046627 @default.
- W4383301992 hasConceptScore W4383301992C71924100 @default.
- W4383301992 hasConceptScore W4383301992C90924648 @default.
- W4383301992 hasLocation W43833019921 @default.
- W4383301992 hasLocation W43833019922 @default.
- W4383301992 hasOpenAccess W4383301992 @default.
- W4383301992 hasPrimaryLocation W43833019921 @default.
- W4383301992 hasRelatedWork W2030434439 @default.
- W4383301992 hasRelatedWork W2050439103 @default.
- W4383301992 hasRelatedWork W2218005127 @default.
- W4383301992 hasRelatedWork W2316766300 @default.
- W4383301992 hasRelatedWork W2336352798 @default.
- W4383301992 hasRelatedWork W2394251095 @default.
- W4383301992 hasRelatedWork W2734844744 @default.
- W4383301992 hasRelatedWork W4300630264 @default.
- W4383301992 hasRelatedWork W4306253774 @default.
- W4383301992 hasRelatedWork W3006168697 @default.
- W4383301992 isParatext "false" @default.
- W4383301992 isRetracted "false" @default.
- W4383301992 workType "article" @default.