FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383302332> ?p ?o ?g. }

• W4383302332 abstract "In spite of recent advances made in understanding its progression, cancer is still a leading cause of death across the nations. Molecular pathophysiology of these cancer cells largely differs depending on cancer types and even within the same tumor. Pathological mineralization/calcification is seen in various tissues including breast, prostate, and lung cancer. Osteoblast-like cells derived after trans-differentiation of mesenchymal cells usually drive calcium deposition in various tissues. This study aims to explore the presence of osteoblast-like potential in lung cancer cells and its prevention. ALP assay, ALP staining, nodule formation, RT-PCR, RT-qPCR, and western blot analysis experiments were carried out in lung cancer A549 cells to achieve said objective. Expressions of various osteoblast markers (e.g., ALP, OPN, RUNX2, and Osterix) along with osteoinducer genes (BMP-2 and BMP-4) were observed in A549 cells. Moreover, ALP activity and ability leading to nodule formation revealed the presence of osteoblast-like potential in lung cancer cells. Here, BMP-2 treatment increased expressions of osteoblast transcription factors such as RUNX2 and Osterix, enhanced ALP activity, and augmented calcification in this cell line. It was also observed that antidiabetic metformin inhibited BMP-2 mediated increase in osteoblast-like potential and calcification in these cancer cells. The current study noted that metformin blocked BMP-2 mediated increase in epithelial to mesenchymal transition (EMT) in A549 cells. The above findings for the first time unravel that A549 cells possess osteoblast-like potential which drives lung cancer calcification. Metformin might prevent BMP-2 induced osteoblast-like phenotype of the lung cancer cells with concomitant inhibition of EMT to inhibit lung cancer tissue calcification." @default.
• W4383302332 created "2023-07-07" @default.
• W4383302332 creator A5001221849 @default.
• W4383302332 creator A5010754881 @default.
• W4383302332 creator A5015828997 @default.
• W4383302332 creator A5016345220 @default.
• W4383302332 creator A5037953260 @default.
• W4383302332 creator A5053464054 @default.
• W4383302332 creator A5066327192 @default.
• W4383302332 creator A5068427535 @default.
• W4383302332 creator A5071512707 @default.
• W4383302332 creator A5090842774 @default.
• W4383302332 date "2023-07-06" @default.
• W4383302332 modified "2023-10-16" @default.
• W4383302332 title "Metformin prevents osteoblast‐like potential and calcification in lung cancer A549 cells" @default.
• W4383302332 cites W1967384627 @default.
• W4383302332 cites W1978573204 @default.
• W4383302332 cites W2034950467 @default.
• W4383302332 cites W2050210599 @default.
• W4383302332 cites W2075604674 @default.
• W4383302332 cites W2077521957 @default.
• W4383302332 cites W2144011096 @default.
• W4383302332 cites W2148743978 @default.
• W4383302332 cites W2167696106 @default.
• W4383302332 cites W2189617142 @default.
• W4383302332 cites W2238472783 @default.
• W4383302332 cites W2267145211 @default.
• W4383302332 cites W2289335582 @default.
• W4383302332 cites W2295063361 @default.
• W4383302332 cites W2586928611 @default.
• W4383302332 cites W2588127161 @default.
• W4383302332 cites W2611168395 @default.
• W4383302332 cites W2735285859 @default.
• W4383302332 cites W2736010943 @default.
• W4383302332 cites W2747294052 @default.
• W4383302332 cites W2797134077 @default.
• W4383302332 cites W2799960991 @default.
• W4383302332 cites W2897140439 @default.
• W4383302332 cites W2903691269 @default.
• W4383302332 cites W2909560058 @default.
• W4383302332 cites W2912045866 @default.
• W4383302332 cites W2937270878 @default.
• W4383302332 cites W2967189837 @default.
• W4383302332 cites W2983440426 @default.
• W4383302332 cites W2988368565 @default.
• W4383302332 cites W3084250906 @default.
• W4383302332 cites W3092689961 @default.
• W4383302332 cites W3109750806 @default.
• W4383302332 cites W3118744118 @default.
• W4383302332 cites W3118858701 @default.
• W4383302332 cites W4281879239 @default.
• W4383302332 cites W4297325541 @default.
• W4383302332 cites W4445544 @default.
• W4383302332 doi "https://doi.org/10.1002/jbt.23454" @default.
• W4383302332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37409753" @default.
• W4383302332 hasPublicationYear "2023" @default.
• W4383302332 type Work @default.
• W4383302332 citedByCount "0" @default.
• W4383302332 crossrefType "journal-article" @default.
• W4383302332 hasAuthorship W4383302332A5001221849 @default.
• W4383302332 hasAuthorship W4383302332A5010754881 @default.
• W4383302332 hasAuthorship W4383302332A5015828997 @default.
• W4383302332 hasAuthorship W4383302332A5016345220 @default.
• W4383302332 hasAuthorship W4383302332A5037953260 @default.
• W4383302332 hasAuthorship W4383302332A5053464054 @default.
• W4383302332 hasAuthorship W4383302332A5066327192 @default.
• W4383302332 hasAuthorship W4383302332A5068427535 @default.
• W4383302332 hasAuthorship W4383302332A5071512707 @default.
• W4383302332 hasAuthorship W4383302332A5090842774 @default.
• W4383302332 hasConcept C121608353 @default.
• W4383302332 hasConcept C126322002 @default.
• W4383302332 hasConcept C185592680 @default.
• W4383302332 hasConcept C198826908 @default.
• W4383302332 hasConcept C202751555 @default.
• W4383302332 hasConcept C2776256026 @default.
• W4383302332 hasConcept C2776363554 @default.
• W4383302332 hasConcept C2778260815 @default.
• W4383302332 hasConcept C2779013556 @default.
• W4383302332 hasConcept C2780309369 @default.
• W4383302332 hasConcept C2780804394 @default.
• W4383302332 hasConcept C502942594 @default.
• W4383302332 hasConcept C55493867 @default.
• W4383302332 hasConcept C71924100 @default.
• W4383302332 hasConcept C76419328 @default.
• W4383302332 hasConcept C81729549 @default.
• W4383302332 hasConcept C86803240 @default.
• W4383302332 hasConcept C95444343 @default.
• W4383302332 hasConcept C96232424 @default.
• W4383302332 hasConceptScore W4383302332C121608353 @default.
• W4383302332 hasConceptScore W4383302332C126322002 @default.
• W4383302332 hasConceptScore W4383302332C185592680 @default.
• W4383302332 hasConceptScore W4383302332C198826908 @default.
• W4383302332 hasConceptScore W4383302332C202751555 @default.
• W4383302332 hasConceptScore W4383302332C2776256026 @default.
• W4383302332 hasConceptScore W4383302332C2776363554 @default.
• W4383302332 hasConceptScore W4383302332C2778260815 @default.
• W4383302332 hasConceptScore W4383302332C2779013556 @default.
• W4383302332 hasConceptScore W4383302332C2780309369 @default.
• W4383302332 hasConceptScore W4383302332C2780804394 @default.
• W4383302332 hasConceptScore W4383302332C502942594 @default.

• next