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- W4383302502 abstract "To summarize recent developments in the diagnosis and management of patients with anaplastic thyroid cancer (ATC).An updated edition of the Classification of Endocrine and Neuroendocrine Tumors was released by the World Health Organization (WHO), in which squamous cell carcinoma of the thyroid are now a subtype of ATC. Broader access to next generation sequencing has allowed better understanding of the molecular mechanisms driving ATC and improved prognostication. BRAF-targeted therapies revolutionized the treatment of advanced/metastatic BRAFV600E -mutated ATC, offering significant clinical benefit and allowing better locoregional control of disease through the neoadjuvant approach. However, inevitable development of resistance mechanisms represents a major challenge. Addition of immunotherapy to BRAF/MEK inhibition has shown very promising results and significant improvement in survival outcomes.Major advancements took place in the characterization and management of ATC in recent years, especially in patients with a BRAF V600E mutation. Still, no curative treatment is available, and options are limited once resistance to currently available BRAF-targeted therapies develops. Additionally, there is still a need for more effective treatments for patients without a BRAF mutation." @default.
- W4383302502 created "2023-07-07" @default.
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- W4383302502 date "2023-07-06" @default.
- W4383302502 modified "2023-09-30" @default.
- W4383302502 title "Recent advances in anaplastic thyroid cancer management" @default.
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- W4383302502 doi "https://doi.org/10.1097/med.0000000000000823" @default.
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