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- W4383303056 abstract "FGFR alterations in urothelial carcinoma are key driver alterations of tumorigenesis and are long recognized. In 2019 the Food and Drug Administration (FDA) approved the first pan-FGFR inhibitor, as the first specific targeted therapy in urothelial carcinoma. To receive the drug, alteration testing is required, and only alteration carriers can profit of this new agent. Due to this clinical need of detection and analysis of FGFR, here we describe two distinct and specific analytical methodologies: the SNaPshot analysis of nine FGFR3 point mutations and the QIAGEN therascreen® FGFR RGQ RT-PCR Kit, the FDA-approved companion diagnostic kit." @default.
- W4383303056 created "2023-07-07" @default.
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- W4383303056 date "2023-01-01" @default.
- W4383303056 modified "2023-09-24" @default.
- W4383303056 title "Evaluation of FGFR Alteration Status in Urothelial Tumors" @default.
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- W4383303056 doi "https://doi.org/10.1007/978-1-0716-3291-8_17" @default.
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