FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383313214> ?p ?o ?g. }

• W4383313214 endingPage "247" @default.
• W4383313214 startingPage "242" @default.
• W4383313214 abstract "The scientific review shows the role of miRNA in the development of liver diseases, namely hepatocellular carcinoma. To write the article, we have searched for information in the Scopus, Web of Science, MedLine, PubMed, Google Scholar, ­EMBASE, Global Health, The Cochrane Library databases. In the development of hepatocellular carcinoma, the role of miRNAs involved in the regulation of the cell cycle, apoptosis, invasion, metastasis, and angiogenesis is emphasized. Scientists believe that loss of ­miR-122 expression in liver cancer correlates with inhibition of the liver phenotype and increased risk of metastasis. It is noted that the development of hepatocellular carcinoma is accompanied by an increase in the level of let-7, miR-26, miR-101 and a decrease in the concentration of miR-17-92, miR-181, miR-221 in blood serum, which can be used as diagnostic criteria. MiR-21 is considered a typical onco-microRNA and the level of circulating miR-21 in peripheral blood can serve as a potential biomarker of the early stage of hepatocellular carcinoma. In hepatocellular carcinoma, a low content of miR-34 is noted, which leads to the activation of the cyclin Е and an increase in the proliferative potential, which favors hepatocarcinogenesis. MiR-34a has an inhibitory effect on almost all oncogenic cellular processes. The researchers demonstrated that the change in the microRNA spectrum is mediated by the primary change in the generation of some circular single-stranded RNAs — circular RNAs. Thus, scientific studies of recent years confirm that miRNAs in the development of hepatocellular carcinoma are involved in the regulation of the cell cycle, apoptosis, invasion, metastasis, angiogenesis. As a potential biomarker of the early stage of hepatocellular carcinoma, the researchers identify the level of miR-21 in blood serum and consider it a typical onco-microRNA. MiR-34a has an inhibitory effect on almost all oncogenic cellular processes in hepatocellular carcinoma. Therefore, microRNAs play a very important role in the development of hepatocellular carcinoma and can be used as diagnostic and prognostic criteria, and factors of pathogenesis whose medicinal modulation will contribute to increasing the effectiveness of therapy." @default.
• W4383313214 created "2023-07-07" @default.
• W4383313214 creator A5053832118 @default.
• W4383313214 creator A5090489728 @default.
• W4383313214 date "2023-07-06" @default.
• W4383313214 modified "2023-09-28" @default.
• W4383313214 title "The role of microRNA in the development of liver diseases. Part 2" @default.
• W4383313214 cites W1787182146 @default.
• W4383313214 cites W1864716429 @default.
• W4383313214 cites W1977170922 @default.
• W4383313214 cites W1998404710 @default.
• W4383313214 cites W2019867706 @default.
• W4383313214 cites W2021369237 @default.
• W4383313214 cites W2030399670 @default.
• W4383313214 cites W2062117233 @default.
• W4383313214 cites W2127461938 @default.
• W4383313214 cites W2131255346 @default.
• W4383313214 cites W2152035403 @default.
• W4383313214 cites W2175027995 @default.
• W4383313214 cites W2213848118 @default.
• W4383313214 cites W2218621540 @default.
• W4383313214 cites W2267171780 @default.
• W4383313214 cites W2545725900 @default.
• W4383313214 cites W2558790575 @default.
• W4383313214 cites W2605409877 @default.
• W4383313214 cites W2766673934 @default.
• W4383313214 cites W2768701455 @default.
• W4383313214 cites W2777621778 @default.
• W4383313214 cites W2782110161 @default.
• W4383313214 cites W2787451213 @default.
• W4383313214 cites W2797863673 @default.
• W4383313214 cites W2803304758 @default.
• W4383313214 cites W2809556937 @default.
• W4383313214 cites W2976877817 @default.
• W4383313214 cites W3117199797 @default.
• W4383313214 cites W3153625340 @default.
• W4383313214 cites W3170661590 @default.
• W4383313214 cites W3185726495 @default.
• W4383313214 cites W4229439542 @default.
• W4383313214 cites W791787195 @default.
• W4383313214 doi "https://doi.org/10.22141/2224-0551.18.3.2023.1593" @default.
• W4383313214 hasPublicationYear "2023" @default.
• W4383313214 type Work @default.
• W4383313214 citedByCount "0" @default.
• W4383313214 crossrefType "journal-article" @default.
• W4383313214 hasAuthorship W4383313214A5053832118 @default.
• W4383313214 hasAuthorship W4383313214A5090489728 @default.
• W4383313214 hasBestOaLocation W43833132141 @default.
• W4383313214 hasConcept C104317684 @default.
• W4383313214 hasConcept C121608353 @default.
• W4383313214 hasConcept C126322002 @default.
• W4383313214 hasConcept C143998085 @default.
• W4383313214 hasConcept C145059251 @default.
• W4383313214 hasConcept C190283241 @default.
• W4383313214 hasConcept C2776231280 @default.
• W4383313214 hasConcept C2776478404 @default.
• W4383313214 hasConcept C2778019345 @default.
• W4383313214 hasConcept C2779013556 @default.
• W4383313214 hasConcept C2780394083 @default.
• W4383313214 hasConcept C2781197716 @default.
• W4383313214 hasConcept C29537977 @default.
• W4383313214 hasConcept C502942594 @default.
• W4383313214 hasConcept C54355233 @default.
• W4383313214 hasConcept C60644358 @default.
• W4383313214 hasConcept C71924100 @default.
• W4383313214 hasConcept C86803240 @default.
• W4383313214 hasConcept C95190672 @default.
• W4383313214 hasConceptScore W4383313214C104317684 @default.
• W4383313214 hasConceptScore W4383313214C121608353 @default.
• W4383313214 hasConceptScore W4383313214C126322002 @default.
• W4383313214 hasConceptScore W4383313214C143998085 @default.
• W4383313214 hasConceptScore W4383313214C145059251 @default.
• W4383313214 hasConceptScore W4383313214C190283241 @default.
• W4383313214 hasConceptScore W4383313214C2776231280 @default.
• W4383313214 hasConceptScore W4383313214C2776478404 @default.
• W4383313214 hasConceptScore W4383313214C2778019345 @default.
• W4383313214 hasConceptScore W4383313214C2779013556 @default.
• W4383313214 hasConceptScore W4383313214C2780394083 @default.
• W4383313214 hasConceptScore W4383313214C2781197716 @default.
• W4383313214 hasConceptScore W4383313214C29537977 @default.
• W4383313214 hasConceptScore W4383313214C502942594 @default.
• W4383313214 hasConceptScore W4383313214C54355233 @default.
• W4383313214 hasConceptScore W4383313214C60644358 @default.
• W4383313214 hasConceptScore W4383313214C71924100 @default.
• W4383313214 hasConceptScore W4383313214C86803240 @default.
• W4383313214 hasConceptScore W4383313214C95190672 @default.
• W4383313214 hasIssue "3" @default.
• W4383313214 hasLocation W43833132141 @default.
• W4383313214 hasOpenAccess W4383313214 @default.
• W4383313214 hasPrimaryLocation W43833132141 @default.
• W4383313214 hasRelatedWork W1975859778 @default.
• W4383313214 hasRelatedWork W2128964826 @default.
• W4383313214 hasRelatedWork W2358524972 @default.
• W4383313214 hasRelatedWork W2363619548 @default.
• W4383313214 hasRelatedWork W2374913185 @default.
• W4383313214 hasRelatedWork W2375332334 @default.
• W4383313214 hasRelatedWork W2386235739 @default.
• W4383313214 hasRelatedWork W4283771460 @default.

• next