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• W4383313364 abstract "Abstract Sleep spindles are a hallmark of non-REM sleep and play a fundamental role in memory consolidation. Alterations in these spindles are emerging as sensitive biomarkers for neurodegenerative diseases of ageing. Understanding the clinical presentations associated with spindle alterations may help to elucidate the functional role of these distinct electroencephalographic oscillations and the pathophysiology of sleep and neurodegenerative disorders. Here, we use a data-driven approach to examine the sleep, memory and default mode network connectivity phenotypes associated with sleep spindle architecture in older adults (mean age = 66 years). Participants were recruited from a specialist clinic for early diagnosis and intervention for cognitive decline, with a proportion showing mild cognitive deficits on neuropsychological testing. In a sample of 88 people who underwent memory assessment, overnight polysomnography and resting state fMRI, a k-means cluster analysis was applied to spindle measures of interest: fast spindle density, spindle duration and spindle amplitude. This resulted in three clusters, characterised by preserved spindle architecture with higher fast spindle density and longer spindle duration (Cluster 1), and alterations in spindle architecture (Clusters 2 and 3). These clusters were further characterised by reduced memory (Clusters 2 and 3) and nocturnal hypoxemia, associated with sleep apnea (Cluster 3). Resting state fMRI analysis confirmed that default mode connectivity was related to spindle architecture, although directionality of this relationship differed across the cluster groups. Together these results confirm a diversity in spindle architecture in older adults, associated with clinically meaningful phenotypes, including memory function and sleep apnea. They suggest that resting state default mode connectivity during the awake state can be associated with sleep spindle architecture, however this is highly dependent on clinical phenotype. Establishing relationships between clinical and neuroimaging features and sleep spindle alterations, will advance our understanding of the bidirectional relationships between sleep changes and neurodegenerative diseases of ageing." @default.
• W4383313364 created "2023-07-07" @default.
• W4383313364 creator A5004639458 @default.
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• W4383313364 date "2023-07-06" @default.
• W4383313364 modified "2023-09-26" @default.
• W4383313364 title "Sleep spindle architecture associated with distinct clinical phenotypes in older adults at risk for dementia" @default.
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• W4383313364 doi "https://doi.org/10.1101/2023.07.03.23292167" @default.
• W4383313364 hasPublicationYear "2023" @default.

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