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• W4383313400 abstract "BackgroundSugammadex has been associated with increases in the bispectral index (BIS). We evaluated the effects of sugammadex administration on quantitative electroencephalographic (EEG) and electromyographic (EMG) measures.MethodsWe performed a prospective observational study of adult male patients undergoing robot-assisted radical prostatectomy. All patients received a sevoflurane-based general anaesthetic and a continuous infusion of rocuronium, which was reversed with 2 mg kg−1 of sugammadex i.v. BIS, EEG, and EMG measures were captured with the BIS Vista™ monitor.ResultsTwenty-five patients were included in this study. Compared with baseline, BIS increased at 4–6 min (β coefficient: 3.63; 95% confidence interval [CI]: 2.22–5.04; P<0.001), spectral edge frequency 95 (SEF95) increased at 2–4 min (β coefficient: 0.29; 95% CI: 0.05–0.52; P=0.016) and 4–6 min (β coefficient: 0.71; 95% CI: 0.47–0.94; P<0.001), and EMG increased at 4–6 min (β coefficient: 1.91; 95% CI: 1.00–2.81; P<0.001) after sugammadex administration. Compared with baseline, increased beta power was observed at 2–4 min (β coefficient: 93; 95% CI: 1–185; P=0.046) and 4–6 min (β coefficient: 208; 95% CI: 116–300; P<0.001), and decreased delta power was observed at 4–6 min (β coefficient: −526.72; 95% CI: −778 to −276; P<0.001) after sugammadex administration. Neither SEF95 nor frequency band data analysis adjusted for EMG showed substantial differences. None of the patients showed clinical signs of awakening.ConclusionsAfter neuromuscular block reversal with 2 mg kg−1 sugammadex, BIS, SEF95, EMG, and beta power showed small but statistically significant increases over time, while delta power decreased." @default.
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• W4383313400 date "2023-09-01" @default.
• W4383313400 modified "2023-10-18" @default.
• W4383313400 title "Effect of sugammadex on processed EEG parameters in patients undergoing robot-assisted radical prostatectomy" @default.
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• W4383313400 doi "https://doi.org/10.1016/j.bja.2023.06.001" @default.
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