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• W4383313402 abstract "Abstract Objectives We investigated ERP29 gene role on pharynx squamous cell carcinoma (PSCC) progression in cisplatin (CDDP)-sensitive (FaDu and LAU-2063), CDDP-treated (FaDu-CDDP), and CDDP-resistant (FaDu-R) cells. Materials and Methods Cells, modified to induce ERP29 overexpression or silencing, were mainly submitted to cell proliferation, necrosis, and migration assay. E-cadherin immunoexpression was assessed in three-dimensional spheroids. WNT, MAPK, and PI3K/AKT pathways genes’ expression were identified by PCR array and validated by qPCR. The influence of microRNA miR-4421 inhibitor on ERP29 expression, and its target genes, were quantified by qPCR. Results ERP29 silencing especially decreased necrotic cell death and increased migration in CDDP-sensitive, treated, and resistant cells, and decreased E-cadherin immunoexpression in CDDP-sensitive three-dimensional-spheroids. During CDDP treatment, ERP29 silencing increased cell proliferation. In CDDP-sensitive cells, ERP29 silencing increased the expression of several genes involved in WNT, MAPK, and PI3K/AKT pathways and decreased CASP9 expression. During CDDP treatment, ERP29 silencing decreased MDM2 and CASP9 expression. In CDDP-resistant cells, ERP29 silencing increased SOS1 , MAPK1 , AKT1 , ITGAV , and CCNE1 ; and decreased KRAS , JUN , MDM2 , and CASP9 expression. In addition, miR-4421 inhibition increased ERP29 expression and decreased MAPK1 , AKT1, and JUN expression in CDDP-sensitive cells; and SOS1 , MAPK1 , AKT1, and ITGAV in CDDP-resistant cells, suggesting a potential therapeutic use for miR-4421 inhibitor. Conclusions ERP29 silencing seems to decrease necrosis and increase migration of PSCC cells by modulating genes enrolled in WNT, MAPK, and PI3K/AKT pathways. Once validated, our data may enable target therapy development based on ensuring ERP29 expression that could benefit patients with CDDP-sensitive and resistant tumors." @default.
• W4383313402 created "2023-07-07" @default.
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• W4383313402 date "2023-07-06" @default.
• W4383313402 modified "2023-10-03" @default.
• W4383313402 title "The impact of<i>ERP29</i>on the progression of pharyngeal squamous cell carcinoma" @default.
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• W4383313402 doi "https://doi.org/10.1101/2023.07.03.23292190" @default.
• W4383313402 hasPublicationYear "2023" @default.
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