FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383313441> ?p ?o ?g. }

• W4383313441 abstract "<sec> <title>BACKGROUND</title> Postreperfusion syndrome can appear during liver transplantation as a deep hemodynamic instability and hyperfibrinolysis. Since its first description in 1987, the incidence has remained unchanged despite efforts made. Meanwhile, the antioxidant effect of ascorbic acid has been investigated in the resuscitation of septic shock and burn patients, with contradictory results. In the field of transplantation, its addition to preservation solutions has been investigated to take advantage of this antioxidant effect. Since postreperfusion syndrome could be considered part of the ischemia reperfusion injury in solid organ transplantation, its beneficial effect on the mitigation of ischemia reperfusion injury and the appearance of postreperfusion syndrome should be investigated. </sec> <sec> <title>OBJECTIVE</title> The aim of this randomized clinical trial is to assess the benefits of ascorbic acid compared to saline regarding postreperfusion syndrome development during adult liver transplantation. </sec> <sec> <title>METHODS</title> This is the protocol of a controlled, randomized, single-center clinical trial carried out at the Hospital Universitario Ramón y Cajal in Spain. A total of 70 subjects over the age of 18 years and undergoing liver transplantation will be assigned by simple randomization to receive either ascorbic acid or saline. The primary outcome will be the differences between groups in the incidence of postreperfusion syndrome. The clinical trial will be carried out under conditions of respect for the fundamental rights of the person and the ethical principles that affect biomedical research with human beings, as well as in accordance with international recommendations contained in the Declaration of Helsinki and its subsequent revisions. </sec> <sec> <title>RESULTS</title> The inclusion process started in 2020. Data cleaning and analyses are expected to take place in the last quarter of 2023 and the results are expected in the beginning of 2024. </sec> <sec> <title>CONCLUSIONS</title> This study is particularly relevant as it will be the first to analyze the clinical effect of ascorbic acid during liver transplantation. We believe that our study addresses an important gap in the knowledge of the possible benefits of ascorbic acid in the field of liver transplantation, and concretely the benefit over postreperfusion syndrome. </sec> <sec> <title>CLINICALTRIAL</title> European Union Drug Regulating Authorities Clinical Trials Database (EudraCT) (2020-000123-39); ClinicalTrials.gov (NCT05754242). </sec>" @default.
• W4383313441 created "2023-07-07" @default.
• W4383313441 creator A5021899132 @default.
• W4383313441 creator A5028443098 @default.
• W4383313441 creator A5041071587 @default.
• W4383313441 creator A5047622848 @default.
• W4383313441 creator A5050088720 @default.
• W4383313441 creator A5050810713 @default.
• W4383313441 creator A5080299298 @default.
• W4383313441 creator A5081107747 @default.
• W4383313441 creator A5086916502 @default.
• W4383313441 creator A5092410089 @default.
• W4383313441 creator A5092410090 @default.
• W4383313441 date "2023-06-29" @default.
• W4383313441 modified "2023-10-14" @default.
• W4383313441 title "INTRAVENOUS ASCORBIC ACID FOR THE PREVENTION OF POSTREPERFUSION SYNDROME IN ORTHOTOPIC LIVER TRANSPLANTATION. Protocol for a randomized controlled trial (Preprint)" @default.
• W4383313441 cites W1821628197 @default.
• W4383313441 cites W1965209096 @default.
• W4383313441 cites W1965526388 @default.
• W4383313441 cites W1972781151 @default.
• W4383313441 cites W1984372443 @default.
• W4383313441 cites W2001608222 @default.
• W4383313441 cites W2002242995 @default.
• W4383313441 cites W2005900950 @default.
• W4383313441 cites W2022423643 @default.
• W4383313441 cites W2034006420 @default.
• W4383313441 cites W2037428425 @default.
• W4383313441 cites W2039066780 @default.
• W4383313441 cites W2045294751 @default.
• W4383313441 cites W2049852876 @default.
• W4383313441 cites W2051263515 @default.
• W4383313441 cites W2059875577 @default.
• W4383313441 cites W2068536957 @default.
• W4383313441 cites W2076858329 @default.
• W4383313441 cites W2084658448 @default.
• W4383313441 cites W2152465977 @default.
• W4383313441 cites W2153875441 @default.
• W4383313441 cites W2160917955 @default.
• W4383313441 cites W2161543670 @default.
• W4383313441 cites W2169482750 @default.
• W4383313441 cites W2170918056 @default.
• W4383313441 cites W2318294335 @default.
• W4383313441 cites W2323784998 @default.
• W4383313441 cites W2560240742 @default.
• W4383313441 cites W2992942311 @default.
• W4383313441 cites W4223650823 @default.
• W4383313441 cites W4312165807 @default.
• W4383313441 cites W4324045740 @default.
• W4383313441 cites W4360976447 @default.
• W4383313441 cites W4367174249 @default.
• W4383313441 doi "https://doi.org/10.2196/preprints.50091" @default.
• W4383313441 hasPublicationYear "2023" @default.
• W4383313441 type Work @default.
• W4383313441 citedByCount "0" @default.
• W4383313441 crossrefType "posted-content" @default.
• W4383313441 hasAuthorship W4383313441A5021899132 @default.
• W4383313441 hasAuthorship W4383313441A5028443098 @default.
• W4383313441 hasAuthorship W4383313441A5041071587 @default.
• W4383313441 hasAuthorship W4383313441A5047622848 @default.
• W4383313441 hasAuthorship W4383313441A5050088720 @default.
• W4383313441 hasAuthorship W4383313441A5050810713 @default.
• W4383313441 hasAuthorship W4383313441A5080299298 @default.
• W4383313441 hasAuthorship W4383313441A5081107747 @default.
• W4383313441 hasAuthorship W4383313441A5086916502 @default.
• W4383313441 hasAuthorship W4383313441A5092410089 @default.
• W4383313441 hasAuthorship W4383313441A5092410090 @default.
• W4383313441 hasConcept C126322002 @default.
• W4383313441 hasConcept C141071460 @default.
• W4383313441 hasConcept C168563851 @default.
• W4383313441 hasConcept C185592680 @default.
• W4383313441 hasConcept C2779609443 @default.
• W4383313441 hasConcept C2911091166 @default.
• W4383313441 hasConcept C2986274086 @default.
• W4383313441 hasConcept C31903555 @default.
• W4383313441 hasConcept C71924100 @default.
• W4383313441 hasConceptScore W4383313441C126322002 @default.
• W4383313441 hasConceptScore W4383313441C141071460 @default.
• W4383313441 hasConceptScore W4383313441C168563851 @default.
• W4383313441 hasConceptScore W4383313441C185592680 @default.
• W4383313441 hasConceptScore W4383313441C2779609443 @default.
• W4383313441 hasConceptScore W4383313441C2911091166 @default.
• W4383313441 hasConceptScore W4383313441C2986274086 @default.
• W4383313441 hasConceptScore W4383313441C31903555 @default.
• W4383313441 hasConceptScore W4383313441C71924100 @default.
• W4383313441 hasLocation W43833134411 @default.
• W4383313441 hasOpenAccess W4383313441 @default.
• W4383313441 hasPrimaryLocation W43833134411 @default.
• W4383313441 hasRelatedWork W2002120878 @default.
• W4383313441 hasRelatedWork W2003938723 @default.
• W4383313441 hasRelatedWork W2047967234 @default.
• W4383313441 hasRelatedWork W2118496982 @default.
• W4383313441 hasRelatedWork W2364998975 @default.
• W4383313441 hasRelatedWork W2369162477 @default.
• W4383313441 hasRelatedWork W2439875401 @default.
• W4383313441 hasRelatedWork W4238867864 @default.
• W4383313441 hasRelatedWork W2519357708 @default.
• W4383313441 hasRelatedWork W2525756941 @default.
• W4383313441 isParatext "false" @default.
• W4383313441 isRetracted "false" @default.
• W4383313441 workType "article" @default.