FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383313576> ?p ?o ?g. }

• W4383313576 endingPage "4422" @default.
• W4383313576 startingPage "4405" @default.
• W4383313576 abstract "Side-chain rotamer prediction is one of the most critical late stages in protein 3D structure building. Highly advanced and specialized algorithms (e.g., FASPR, RASP, SCWRL4, and SCWRL4v) optimize this process by use of rotamer libraries, combinatorial searches, and scoring functions. We seek to identify the sources of key rotamer errors as a basis for correcting and improving the accuracy of protein modeling going forward. In order to evaluate the aforementioned programs, we process 2496 high-quality single-chained all-atom filtered 30% homology protein 3D structures and use discretized rotamer analysis to compare original with calculated structures. Among 513,024 filtered residue records, increased amino acid residue-dependent rotamer errors─associated in particular with polar and charged amino acid residues (ARG, LYS, and GLN)─clearly correlate with increased amino acid residue solvent accessibility and an increased residue tendency toward the adoption of non-canonical off rotamers which modeling programs struggle to predict accurately. Understanding the impact of solvent accessibility now appears key to improved side-chain prediction accuracies." @default.
• W4383313576 created "2023-07-07" @default.
• W4383313576 creator A5018934612 @default.
• W4383313576 creator A5046923713 @default.
• W4383313576 creator A5047865373 @default.
• W4383313576 creator A5055738427 @default.
• W4383313576 creator A5079176233 @default.
• W4383313576 date "2023-07-06" @default.
• W4383313576 modified "2023-10-18" @default.
• W4383313576 title "Solvent Accessibility Promotes Rotamer Errors during Protein Modeling with Major Side-Chain Prediction Programs" @default.
• W4383313576 cites W1574312817 @default.
• W4383313576 cites W1940137454 @default.
• W4383313576 cites W1983277181 @default.
• W4383313576 cites W1983396218 @default.
• W4383313576 cites W1992426410 @default.
• W4383313576 cites W2008708467 @default.
• W4383313576 cites W2009166458 @default.
• W4383313576 cites W2011658408 @default.
• W4383313576 cites W2035620520 @default.
• W4383313576 cites W2106648157 @default.
• W4383313576 cites W2144739764 @default.
• W4383313576 cites W2145778523 @default.
• W4383313576 cites W2150155770 @default.
• W4383313576 cites W2154319440 @default.
• W4383313576 cites W2206429604 @default.
• W4383313576 cites W2231783367 @default.
• W4383313576 cites W2325521056 @default.
• W4383313576 cites W2514016200 @default.
• W4383313576 cites W2770064729 @default.
• W4383313576 cites W2912932504 @default.
• W4383313576 cites W2941939543 @default.
• W4383313576 cites W2994942809 @default.
• W4383313576 cites W3014108899 @default.
• W4383313576 cites W3014576393 @default.
• W4383313576 cites W3100571307 @default.
• W4383313576 cites W3165545667 @default.
• W4383313576 cites W3177828909 @default.
• W4383313576 cites W3186179742 @default.
• W4383313576 cites W3186243460 @default.
• W4383313576 cites W3187251571 @default.
• W4383313576 cites W3197542363 @default.
• W4383313576 cites W3203808025 @default.
• W4383313576 cites W4220659804 @default.
• W4383313576 cites W4235645429 @default.
• W4383313576 cites W4286500588 @default.
• W4383313576 cites W4300861364 @default.
• W4383313576 cites W4327550249 @default.
• W4383313576 cites W4376542635 @default.
• W4383313576 doi "https://doi.org/10.1021/acs.jcim.3c00134" @default.
• W4383313576 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37410883" @default.
• W4383313576 hasPublicationYear "2023" @default.
• W4383313576 type Work @default.
• W4383313576 citedByCount "0" @default.
• W4383313576 crossrefType "journal-article" @default.
• W4383313576 hasAuthorship W4383313576A5018934612 @default.
• W4383313576 hasAuthorship W4383313576A5046923713 @default.
• W4383313576 hasAuthorship W4383313576A5047865373 @default.
• W4383313576 hasAuthorship W4383313576A5055738427 @default.
• W4383313576 hasAuthorship W4383313576A5079176233 @default.
• W4383313576 hasBestOaLocation W43833135761 @default.
• W4383313576 hasConcept C104317684 @default.
• W4383313576 hasConcept C147597530 @default.
• W4383313576 hasConcept C152769699 @default.
• W4383313576 hasConcept C167625842 @default.
• W4383313576 hasConcept C169627665 @default.
• W4383313576 hasConcept C178790620 @default.
• W4383313576 hasConcept C181199279 @default.
• W4383313576 hasConcept C185592680 @default.
• W4383313576 hasConcept C18705241 @default.
• W4383313576 hasConcept C204921945 @default.
• W4383313576 hasConcept C2781338088 @default.
• W4383313576 hasConcept C2994376932 @default.
• W4383313576 hasConcept C32909587 @default.
• W4383313576 hasConcept C41008148 @default.
• W4383313576 hasConcept C47701112 @default.
• W4383313576 hasConcept C521977710 @default.
• W4383313576 hasConcept C55493867 @default.
• W4383313576 hasConcept C70721500 @default.
• W4383313576 hasConcept C71240020 @default.
• W4383313576 hasConcept C86803240 @default.
• W4383313576 hasConceptScore W4383313576C104317684 @default.
• W4383313576 hasConceptScore W4383313576C147597530 @default.
• W4383313576 hasConceptScore W4383313576C152769699 @default.
• W4383313576 hasConceptScore W4383313576C167625842 @default.
• W4383313576 hasConceptScore W4383313576C169627665 @default.
• W4383313576 hasConceptScore W4383313576C178790620 @default.
• W4383313576 hasConceptScore W4383313576C181199279 @default.
• W4383313576 hasConceptScore W4383313576C185592680 @default.
• W4383313576 hasConceptScore W4383313576C18705241 @default.
• W4383313576 hasConceptScore W4383313576C204921945 @default.
• W4383313576 hasConceptScore W4383313576C2781338088 @default.
• W4383313576 hasConceptScore W4383313576C2994376932 @default.
• W4383313576 hasConceptScore W4383313576C32909587 @default.
• W4383313576 hasConceptScore W4383313576C41008148 @default.
• W4383313576 hasConceptScore W4383313576C47701112 @default.
• W4383313576 hasConceptScore W4383313576C521977710 @default.
• W4383313576 hasConceptScore W4383313576C55493867 @default.
• W4383313576 hasConceptScore W4383313576C70721500 @default.

• next