Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383313642> ?p ?o ?g. }
- W4383313642 abstract "Intravenous infusion of human alpha calcitonin gene-related peptide (h-α-CGRP) has been applied to explore migraine pathogenesis and cerebral hemodynamics during the past three decades. Cumulative data implicate h-α-CGRP in regulating the vascular tone. In this systematic review, we searched PubMed and EMBASE for clinical studies investigating the vascular changes upon intravenous infusion of h-α-CGRP in humans. A total of 386 studies were screened by title and abstract. Of these, 11 studies with 61 healthy participants and 177 participants diagnosed with migraine were included. Several studies reported hemodynamic effects including flushing, palpitation, warm sensation, heart rate (HR), mean arterial blood pressure (MABP), mean blood flow velocity of middle cerebral artery (mean V MCA ), and diameter of superficial temporal artery (STA). Upon the start of h-α-CGRP infusion, 163 of 165 (99%) participants had flushing, 98 of 155 (63%) participants reported palpitation, and 160 of 165 (97%) participants reported warm sensation. HR increased with 14%–58% and MABP decreased with 7%–12%. The mean V MCA was decreased with 9.5%–21%, and the diameter of the STA was dilated with 41%–43%. The vascular changes lasted from 20 to >120 min. Intravenous infusion of h-α-CGRP caused a universal vasodilation without any serious adverse events. The involvement of CGRP in the systemic hemodynamic raises concerns regarding long-term blockade of CGRP in migraine patients with and without cardiovascular complications." @default.
- W4383313642 created "2023-07-07" @default.
- W4383313642 creator A5006074871 @default.
- W4383313642 creator A5038565020 @default.
- W4383313642 creator A5039644860 @default.
- W4383313642 creator A5058013247 @default.
- W4383313642 date "2023-07-06" @default.
- W4383313642 modified "2023-09-26" @default.
- W4383313642 title "The vascular role of CGRP: a systematic review of human studies" @default.
- W4383313642 cites W1506673182 @default.
- W4383313642 cites W1983153788 @default.
- W4383313642 cites W1985194414 @default.
- W4383313642 cites W1985517517 @default.
- W4383313642 cites W2001650386 @default.
- W4383313642 cites W2012417196 @default.
- W4383313642 cites W2020983642 @default.
- W4383313642 cites W2022018134 @default.
- W4383313642 cites W2032186292 @default.
- W4383313642 cites W2042885920 @default.
- W4383313642 cites W2050373339 @default.
- W4383313642 cites W2053420136 @default.
- W4383313642 cites W2074939801 @default.
- W4383313642 cites W2077254476 @default.
- W4383313642 cites W2085840750 @default.
- W4383313642 cites W2086727023 @default.
- W4383313642 cites W2112252385 @default.
- W4383313642 cites W2125066141 @default.
- W4383313642 cites W2129181629 @default.
- W4383313642 cites W2139878437 @default.
- W4383313642 cites W2152848856 @default.
- W4383313642 cites W2161310038 @default.
- W4383313642 cites W2162942726 @default.
- W4383313642 cites W2165079882 @default.
- W4383313642 cites W2307975700 @default.
- W4383313642 cites W2317957978 @default.
- W4383313642 cites W2466122216 @default.
- W4383313642 cites W2609803856 @default.
- W4383313642 cites W2736411845 @default.
- W4383313642 cites W2782019574 @default.
- W4383313642 cites W2891221883 @default.
- W4383313642 cites W2898958234 @default.
- W4383313642 cites W2900267857 @default.
- W4383313642 cites W2919152931 @default.
- W4383313642 cites W2941010478 @default.
- W4383313642 cites W2943483025 @default.
- W4383313642 cites W2947247420 @default.
- W4383313642 cites W2947345259 @default.
- W4383313642 cites W2980853513 @default.
- W4383313642 cites W2981902069 @default.
- W4383313642 cites W2999849670 @default.
- W4383313642 cites W3014245175 @default.
- W4383313642 cites W3020716837 @default.
- W4383313642 cites W3026566790 @default.
- W4383313642 cites W3037111965 @default.
- W4383313642 cites W3050017463 @default.
- W4383313642 cites W3058210245 @default.
- W4383313642 cites W3097918031 @default.
- W4383313642 cites W3111709648 @default.
- W4383313642 cites W3118615836 @default.
- W4383313642 cites W3120635632 @default.
- W4383313642 cites W3120929599 @default.
- W4383313642 cites W3133632825 @default.
- W4383313642 cites W3147775715 @default.
- W4383313642 cites W3153940137 @default.
- W4383313642 cites W3169710292 @default.
- W4383313642 cites W3175397775 @default.
- W4383313642 cites W3181317618 @default.
- W4383313642 cites W3204374415 @default.
- W4383313642 cites W4210507365 @default.
- W4383313642 cites W4210569896 @default.
- W4383313642 cites W4301187656 @default.
- W4383313642 doi "https://doi.org/10.3389/fneur.2023.1204734" @default.
- W4383313642 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37483452" @default.
- W4383313642 hasPublicationYear "2023" @default.
- W4383313642 type Work @default.
- W4383313642 citedByCount "0" @default.
- W4383313642 crossrefType "journal-article" @default.
- W4383313642 hasAuthorship W4383313642A5006074871 @default.
- W4383313642 hasAuthorship W4383313642A5038565020 @default.
- W4383313642 hasAuthorship W4383313642A5039644860 @default.
- W4383313642 hasAuthorship W4383313642A5058013247 @default.
- W4383313642 hasBestOaLocation W43833136421 @default.
- W4383313642 hasConcept C118303440 @default.
- W4383313642 hasConcept C120770815 @default.
- W4383313642 hasConcept C126322002 @default.
- W4383313642 hasConcept C163170386 @default.
- W4383313642 hasConcept C164705383 @default.
- W4383313642 hasConcept C170493617 @default.
- W4383313642 hasConcept C178853913 @default.
- W4383313642 hasConcept C197934379 @default.
- W4383313642 hasConcept C2778541695 @default.
- W4383313642 hasConcept C2779627488 @default.
- W4383313642 hasConcept C42219234 @default.
- W4383313642 hasConcept C71924100 @default.
- W4383313642 hasConcept C84393581 @default.
- W4383313642 hasConceptScore W4383313642C118303440 @default.
- W4383313642 hasConceptScore W4383313642C120770815 @default.
- W4383313642 hasConceptScore W4383313642C126322002 @default.
- W4383313642 hasConceptScore W4383313642C163170386 @default.
- W4383313642 hasConceptScore W4383313642C164705383 @default.