Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383313666> ?p ?o ?g. }
- W4383313666 abstract "During the early stages of human large ribosomal subunit (60 S ) biogenesis, an ensemble of assembly factors establishes and fine-tunes the essential RNA functional centers of pre-60 S particles by an unknown mechanism. Here, we report a series of cryo–electron microscopy structures of human nucleolar and nuclear pre-60 S assembly intermediates at resolutions of 2.5 to 3.2 angstroms. These structures show how protein interaction hubs tether assembly factor complexes to nucleolar particles and how guanosine triphosphatases and adenosine triphosphatase couple irreversible nucleotide hydrolysis steps to the installation of functional centers. Nuclear stages highlight how a conserved RNA-processing complex, the rixosome, couples large-scale RNA conformational changes with pre–ribosomal RNA processing by the RNA degradation machinery. Our ensemble of human pre-60 S particles provides a rich foundation with which to elucidate the molecular principles of ribosome formation." @default.
- W4383313666 created "2023-07-07" @default.
- W4383313666 creator A5031074465 @default.
- W4383313666 creator A5036579138 @default.
- W4383313666 date "2023-07-07" @default.
- W4383313666 modified "2023-10-10" @default.
- W4383313666 title "Principles of human pre-60 <i>S</i> biogenesis" @default.
- W4383313666 cites W1918704078 @default.
- W4383313666 cites W1955957810 @default.
- W4383313666 cites W1964480899 @default.
- W4383313666 cites W1970546448 @default.
- W4383313666 cites W1976337128 @default.
- W4383313666 cites W2009110345 @default.
- W4383313666 cites W2013779315 @default.
- W4383313666 cites W2014874299 @default.
- W4383313666 cites W2020068229 @default.
- W4383313666 cites W2037055277 @default.
- W4383313666 cites W2041157094 @default.
- W4383313666 cites W2043274355 @default.
- W4383313666 cites W2044386270 @default.
- W4383313666 cites W2046797733 @default.
- W4383313666 cites W2080190754 @default.
- W4383313666 cites W2083968636 @default.
- W4383313666 cites W2084596957 @default.
- W4383313666 cites W2085098052 @default.
- W4383313666 cites W2092594973 @default.
- W4383313666 cites W2099385135 @default.
- W4383313666 cites W2101610042 @default.
- W4383313666 cites W2107025693 @default.
- W4383313666 cites W2124693268 @default.
- W4383313666 cites W2127322768 @default.
- W4383313666 cites W2130966021 @default.
- W4383313666 cites W2142161929 @default.
- W4383313666 cites W2144081223 @default.
- W4383313666 cites W2154241726 @default.
- W4383313666 cites W2155858493 @default.
- W4383313666 cites W2168029884 @default.
- W4383313666 cites W2188223075 @default.
- W4383313666 cites W2226203144 @default.
- W4383313666 cites W2271648019 @default.
- W4383313666 cites W2347171555 @default.
- W4383313666 cites W2407366427 @default.
- W4383313666 cites W2546735327 @default.
- W4383313666 cites W2557904026 @default.
- W4383313666 cites W2587625522 @default.
- W4383313666 cites W2592503616 @default.
- W4383313666 cites W2593511418 @default.
- W4383313666 cites W2624125560 @default.
- W4383313666 cites W2728385286 @default.
- W4383313666 cites W2734736563 @default.
- W4383313666 cites W2751387723 @default.
- W4383313666 cites W2765112592 @default.
- W4383313666 cites W2765837144 @default.
- W4383313666 cites W2770436140 @default.
- W4383313666 cites W2775096538 @default.
- W4383313666 cites W2788198022 @default.
- W4383313666 cites W2788833468 @default.
- W4383313666 cites W2793021023 @default.
- W4383313666 cites W2794358105 @default.
- W4383313666 cites W2799964814 @default.
- W4383313666 cites W2803479625 @default.
- W4383313666 cites W2891167139 @default.
- W4383313666 cites W2895261801 @default.
- W4383313666 cites W2895950820 @default.
- W4383313666 cites W2897056819 @default.
- W4383313666 cites W2901258541 @default.
- W4383313666 cites W2901941802 @default.
- W4383313666 cites W2903232633 @default.
- W4383313666 cites W2912949690 @default.
- W4383313666 cites W2944819910 @default.
- W4383313666 cites W2946528398 @default.
- W4383313666 cites W2950967305 @default.
- W4383313666 cites W2966070481 @default.
- W4383313666 cites W2973457155 @default.
- W4383313666 cites W2980434314 @default.
- W4383313666 cites W2982544614 @default.
- W4383313666 cites W2988833431 @default.
- W4383313666 cites W3000744971 @default.
- W4383313666 cites W3043079810 @default.
- W4383313666 cites W3043270172 @default.
- W4383313666 cites W3044914877 @default.
- W4383313666 cites W3083406432 @default.
- W4383313666 cites W3085713937 @default.
- W4383313666 cites W3110425738 @default.
- W4383313666 cites W3133656302 @default.
- W4383313666 cites W3168514793 @default.
- W4383313666 cites W3177828909 @default.
- W4383313666 cites W3186624543 @default.
- W4383313666 cites W3196605237 @default.
- W4383313666 cites W3197208223 @default.
- W4383313666 cites W3213779066 @default.
- W4383313666 cites W4213206917 @default.
- W4383313666 cites W4214539901 @default.
- W4383313666 cites W4221097859 @default.
- W4383313666 cites W4225166092 @default.
- W4383313666 cites W4250894749 @default.
- W4383313666 cites W4295427504 @default.
- W4383313666 cites W4297264236 @default.
- W4383313666 cites W4308616699 @default.
- W4383313666 cites W4308653678 @default.