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- W4383313698 endingPage "393" @default.
- W4383313698 startingPage "375" @default.
- W4383313698 abstract "During natural aging, skeletal muscle experiences impairments in mechanical performance due, in part, to changes in muscle architecture and size, notably with a loss of muscle cross-sectional area (CSA). Another important factor that has received less attention is the shortening of fascicle length (FL), potentially reflective of a decrease in serial sarcomere number (SSN). Interventions that promote the growth of new serial sarcomeres, such as chronic stretching and eccentric-biased resistance training, have been suggested as potential ways to mitigate age-related impairments in muscle function. Although current research suggests it is possible to stimulate serial sarcomerogenesis in muscle in old age, the magnitude of sarcomerogenesis may be less than in young muscle. This blunted effect may be partly due to age-related impairments in the pathways regulating mechanotransduction, muscle gene expression, and protein synthesis, as some have been implicated in SSN adaptation. The purpose of this review was to investigate the impact of aging on the ability for serial sarcomerogenesis and elucidate the molecular pathways that may limit serial sarcomerogenesis in old age. Age-related changes in mechanistic target of rapamycin (mTOR), insulin-like growth factor 1 (IGF-1), myostatin, and serum response factor signaling, muscle ring finger protein (MuRFs), and satellite cells may hinder serial sarcomerogenesis. In addition, our current understanding of SSN in older humans is limited by assumptions based on ultrasound-derived fascicle length. Future research should explore the effects of age-related changes in the identified pathways on the ability to stimulate serial sarcomerogenesis, and better estimate SSN adaptations to gain a deeper understanding of the adaptability of muscle in old age." @default.
- W4383313698 created "2023-07-07" @default.
- W4383313698 creator A5007411954 @default.
- W4383313698 creator A5039146557 @default.
- W4383313698 creator A5089116790 @default.
- W4383313698 creator A5090801711 @default.
- W4383313698 date "2023-08-01" @default.
- W4383313698 modified "2023-09-26" @default.
- W4383313698 title "The importance of serial sarcomere addition for muscle function and the impact of aging" @default.
- W4383313698 cites W1419114000 @default.
- W4383313698 cites W1500762813 @default.
- W4383313698 cites W1531013203 @default.
- W4383313698 cites W1535001084 @default.
- W4383313698 cites W1565396177 @default.
- W4383313698 cites W1567217814 @default.
- W4383313698 cites W1572889665 @default.
- W4383313698 cites W1586159393 @default.
- W4383313698 cites W1774689153 @default.
- W4383313698 cites W1838896829 @default.
- W4383313698 cites W1847176293 @default.
- W4383313698 cites W192708085 @default.
- W4383313698 cites W1930882462 @default.
- W4383313698 cites W1964771425 @default.
- W4383313698 cites W1964859063 @default.
- W4383313698 cites W1969887716 @default.
- W4383313698 cites W1970060526 @default.
- W4383313698 cites W1971956967 @default.
- W4383313698 cites W1972714808 @default.
- W4383313698 cites W1973434197 @default.
- W4383313698 cites W1976262464 @default.
- W4383313698 cites W1976600389 @default.
- W4383313698 cites W1978514943 @default.
- W4383313698 cites W1979125524 @default.
- W4383313698 cites W1981200316 @default.
- W4383313698 cites W1985127050 @default.
- W4383313698 cites W1985708073 @default.
- W4383313698 cites W1987030748 @default.
- W4383313698 cites W1988060154 @default.
- W4383313698 cites W1989052865 @default.
- W4383313698 cites W1993799953 @default.
- W4383313698 cites W1996849889 @default.
- W4383313698 cites W1998813619 @default.
- W4383313698 cites W2004152246 @default.
- W4383313698 cites W2004871261 @default.
- W4383313698 cites W2005898155 @default.
- W4383313698 cites W2007452508 @default.
- W4383313698 cites W2008236912 @default.
- W4383313698 cites W2009227185 @default.
- W4383313698 cites W2009876325 @default.
- W4383313698 cites W2010741278 @default.
- W4383313698 cites W2011367132 @default.
- W4383313698 cites W2011982245 @default.
- W4383313698 cites W2013833790 @default.
- W4383313698 cites W2014608788 @default.
- W4383313698 cites W2016628864 @default.
- W4383313698 cites W2016771752 @default.
- W4383313698 cites W2019448053 @default.
- W4383313698 cites W2021903920 @default.
- W4383313698 cites W2022204551 @default.
- W4383313698 cites W2022253315 @default.
- W4383313698 cites W2022487205 @default.
- W4383313698 cites W2023087041 @default.
- W4383313698 cites W2023421135 @default.
- W4383313698 cites W2028656620 @default.
- W4383313698 cites W2029550367 @default.
- W4383313698 cites W2029914169 @default.
- W4383313698 cites W2030282666 @default.
- W4383313698 cites W2032263402 @default.
- W4383313698 cites W2032977157 @default.
- W4383313698 cites W2036424674 @default.
- W4383313698 cites W2038188196 @default.
- W4383313698 cites W2039014511 @default.
- W4383313698 cites W2039295135 @default.
- W4383313698 cites W2040004746 @default.
- W4383313698 cites W2044192023 @default.
- W4383313698 cites W2046679209 @default.
- W4383313698 cites W2048220430 @default.
- W4383313698 cites W2049946444 @default.
- W4383313698 cites W2050820057 @default.
- W4383313698 cites W2051329192 @default.
- W4383313698 cites W2052823404 @default.
- W4383313698 cites W2052998572 @default.
- W4383313698 cites W2053079324 @default.
- W4383313698 cites W2055207178 @default.
- W4383313698 cites W2056660366 @default.
- W4383313698 cites W2058132072 @default.
- W4383313698 cites W2059088759 @default.
- W4383313698 cites W2059545589 @default.
- W4383313698 cites W2059938268 @default.
- W4383313698 cites W2060223045 @default.
- W4383313698 cites W2060658810 @default.
- W4383313698 cites W2061773099 @default.
- W4383313698 cites W2063025822 @default.
- W4383313698 cites W2063881294 @default.
- W4383313698 cites W2063959543 @default.
- W4383313698 cites W2066949315 @default.
- W4383313698 cites W2067657178 @default.
- W4383313698 cites W2069811586 @default.