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- W4383314139 endingPage "151340" @default.
- W4383314139 startingPage "151340" @default.
- W4383314139 abstract "The biological and clinical significance of aberrant clonal expansions in aged tissues is being intensely discussed. Evidence is accruing that these clones often result from the normal dynamics of cell turnover in our tissues. The aged tissue microenvironment is prone to favour the emergence of specific clones with higher fitness partly because of an overall decline in cell intrinsic regenerative potential of surrounding counterparts. Thus, expanding clones in aged tissues need not to be mechanistically associated with the development of cancer, albeit this is a possibility. We suggest that growth pattern is a critical phenotypic attribute that impacts on the fate of such clonal proliferations. The acquisition of a better proliferative fitness, coupled with a defect in tissue pattern formation, could represent a dangerous mix setting the stage for their evolution towards neoplasia." @default.
- W4383314139 created "2023-07-07" @default.
- W4383314139 creator A5009776674 @default.
- W4383314139 creator A5025805685 @default.
- W4383314139 creator A5091837599 @default.
- W4383314139 date "2023-09-01" @default.
- W4383314139 modified "2023-09-23" @default.
- W4383314139 title "Clones of aging: When better fitness can be dangerous" @default.
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