Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383314332> ?p ?o ?g. }
Showing items 1 to 62 of
62
with 100 items per page.
- W4383314332 endingPage "759" @default.
- W4383314332 startingPage "757" @default.
- W4383314332 abstract "The sulfate donor 3′-phosphoadenosine-5′-phosphosulfate (PAPS) is a near-universal component of sulfur metabolism. In a report by Zhang et al. in this issue of Structure, X-ray crystal structures of the APS kinase domains from human PAPS synthase reveal dynamic substrate recognition and a regulatory “redox switch” analogous to that previously described only in plant APS kinases. The sulfate donor 3′-phosphoadenosine-5′-phosphosulfate (PAPS) is a near-universal component of sulfur metabolism. In a report by Zhang et al. in this issue of Structure, X-ray crystal structures of the APS kinase domains from human PAPS synthase reveal dynamic substrate recognition and a regulatory “redox switch” analogous to that previously described only in plant APS kinases. Redox switching mechanism of the adenosine 5′-phosphosulfate kinase domain (APSK2) of human PAPS synthase 2Zhang et al.StructureMay 18, 2023In BriefPAPS synthetase (PAPSS) catalyzes the biosynthesis of the sulfuryl donor PAPS. Zhang et al. elucidated the catalytic mechanism of the APSK2 domain from the human isoform PAPSS2. They discovered that the absence of an important redox-regulatory element enhances the enzymatic activity of APSK2, which facilitates excess PAPS production and promotes tumorigenesis. Full-Text PDF" @default.
- W4383314332 created "2023-07-07" @default.
- W4383314332 creator A5003137941 @default.
- W4383314332 creator A5085477283 @default.
- W4383314332 date "2023-07-01" @default.
- W4383314332 modified "2023-09-24" @default.
- W4383314332 title "A tale of two switches: Redox regulation of adenosine-5′-phosphosulfate kinase in humans and plants" @default.
- W4383314332 cites W2005607716 @default.
- W4383314332 cites W2032423975 @default.
- W4383314332 cites W2054033517 @default.
- W4383314332 cites W2071578885 @default.
- W4383314332 cites W2162599293 @default.
- W4383314332 cites W2166046905 @default.
- W4383314332 cites W2280933576 @default.
- W4383314332 cites W2954241426 @default.
- W4383314332 cites W3217384050 @default.
- W4383314332 cites W4377020436 @default.
- W4383314332 doi "https://doi.org/10.1016/j.str.2023.06.006" @default.
- W4383314332 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37419098" @default.
- W4383314332 hasPublicationYear "2023" @default.
- W4383314332 type Work @default.
- W4383314332 citedByCount "0" @default.
- W4383314332 crossrefType "journal-article" @default.
- W4383314332 hasAuthorship W4383314332A5003137941 @default.
- W4383314332 hasAuthorship W4383314332A5085477283 @default.
- W4383314332 hasConcept C178790620 @default.
- W4383314332 hasConcept C181199279 @default.
- W4383314332 hasConcept C184235292 @default.
- W4383314332 hasConcept C185592680 @default.
- W4383314332 hasConcept C2780876210 @default.
- W4383314332 hasConcept C34628245 @default.
- W4383314332 hasConcept C55493867 @default.
- W4383314332 hasConcept C55904794 @default.
- W4383314332 hasConceptScore W4383314332C178790620 @default.
- W4383314332 hasConceptScore W4383314332C181199279 @default.
- W4383314332 hasConceptScore W4383314332C184235292 @default.
- W4383314332 hasConceptScore W4383314332C185592680 @default.
- W4383314332 hasConceptScore W4383314332C2780876210 @default.
- W4383314332 hasConceptScore W4383314332C34628245 @default.
- W4383314332 hasConceptScore W4383314332C55493867 @default.
- W4383314332 hasConceptScore W4383314332C55904794 @default.
- W4383314332 hasIssue "7" @default.
- W4383314332 hasLocation W43833143321 @default.
- W4383314332 hasLocation W43833143322 @default.
- W4383314332 hasOpenAccess W4383314332 @default.
- W4383314332 hasPrimaryLocation W43833143321 @default.
- W4383314332 hasRelatedWork W2000745848 @default.
- W4383314332 hasRelatedWork W2021099451 @default.
- W4383314332 hasRelatedWork W2036108519 @default.
- W4383314332 hasRelatedWork W2395380685 @default.
- W4383314332 hasRelatedWork W2604383477 @default.
- W4383314332 hasRelatedWork W2936188404 @default.
- W4383314332 hasRelatedWork W2952478468 @default.
- W4383314332 hasRelatedWork W4232552561 @default.
- W4383314332 hasRelatedWork W2020003695 @default.
- W4383314332 hasRelatedWork W2526641645 @default.
- W4383314332 hasVolume "31" @default.
- W4383314332 isParatext "false" @default.
- W4383314332 isRetracted "false" @default.
- W4383314332 workType "article" @default.