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- W4383337498 endingPage "151338" @default.
- W4383337498 startingPage "151338" @default.
- W4383337498 abstract "Pattern-recognition receptors (PRRs) are critical to recognizing endogenous and exogenous threats to mount a protective proinflammatory innate immune response. PRRs may be located on the outer cell membrane, cytosol, and nucleus. The cGAS/STING signaling pathway is a cytosolic PRR system. Notably, cGAS is also present in the nucleus. The cGAS-mediated recognition of cytosolic dsDNA and its cleavage into cGAMP activates STING. Furthermore, STING activation through its downstream signaling triggers different interferon-stimulating genes (ISGs), initiating the release of type 1 interferons (IFNs) and NF-κB-mediated release of proinflammatory cytokines and molecules. Activating cGAS/STING generates type 1 IFN, which may prevent cellular transformation and cancer development, growth, and metastasis. The current article delineates the impact of the cancer cell-specific cGAS/STING signaling pathway alteration in tumors and its impact on tumor growth and metastasis. This article further discusses different approaches to specifically target cGAS/STING signaling in cancer cells to inhibit tumor growth and metastasis in conjunction with existing anticancer therapies." @default.
- W4383337498 created "2023-07-07" @default.
- W4383337498 creator A5035248018 @default.
- W4383337498 creator A5075490012 @default.
- W4383337498 creator A5081346349 @default.
- W4383337498 date "2023-09-01" @default.
- W4383337498 modified "2023-09-23" @default.
- W4383337498 title "Cancer cell-specific cGAS/STING Signaling pathway in the era of advancing cancer cell biology" @default.
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