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- W4383340872 endingPage "101910" @default.
- W4383340872 startingPage "101910" @default.
- W4383340872 abstract "Cardiac aging is accompanied by changes in the heart at the cellular and molecular levels, leading to alterations in cardiac structure and function. Given today's increasingly aging population, the decline in cardiac function caused by cardiac aging has a significant impact on quality of life. Anti-aging therapies to slow the aging process and attenuate changes in cardiac structure and function have become an important research topic. Treatment with drugs, including metformin, spermidine, rapamycin, resveratrol, astaxanthin, Huolisu oral liquid, and sulforaphane, has been demonstrated be effective in delaying cardiac aging by stimulating autophagy, delaying ventricular remodeling, and reducing oxidative stress and the inflammatory response. Furthermore, caloric restriction has been shown to play an important role in delaying aging of the heart. Many studies in cardiac aging and cardiac aging-related models have demonstrated that Sestrin2 has antioxidant and anti-inflammatory effects, stimulates autophagy, delays aging, regulates mitochondrial function, and inhibits myocardial remodeling by regulation of relevant signaling pathways. Therefore, Sestrin2 is likely to become an important target for anti-myocardial aging therapy." @default.
- W4383340872 created "2023-07-07" @default.
- W4383340872 creator A5017529319 @default.
- W4383340872 creator A5018477849 @default.
- W4383340872 creator A5065196061 @default.
- W4383340872 creator A5084161888 @default.
- W4383340872 date "2023-12-01" @default.
- W4383340872 modified "2023-09-23" @default.
- W4383340872 title "Status of Research on Sestrin2 and Prospects for its Application in Therapeutic Strategies Targeting Myocardial Aging" @default.
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