Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383340940> ?p ?o ?g. }
- W4383340940 abstract "Abstract Fatty liver disease or the accumulation of fat in the liver, has been reported to affect the global population. This comes with an increased risk for the development of fibrosis, cirrhosis, and hepatocellular carcinoma. Yet, little is known about the effects of a diet containing high fat and alcohol towards epigenetic aging, with respect to changes in transcriptional and epigenomic profiles. In this study, we took up a multi-omics approach and integrated gene expression, methylation signals, and chromatin signals to study the epigenomic effects of a high-fat and alcohol-containing diet on mouse hepatocytes. We identified four relevant gene network clusters that were associated with relevant pathways that promote steatosis. Using a machine learning approach, we predict specific transcription factors that might be responsible to modulate the functionally relevant clusters. Finally, we discover four additional CpG loci and validate aging-related differential CpG methylation. Differential CpG methylation linked to aging showed minimal overlap with altered methylation in steatosis." @default.
- W4383340940 created "2023-07-07" @default.
- W4383340940 creator A5001591003 @default.
- W4383340940 creator A5005710292 @default.
- W4383340940 creator A5007663491 @default.
- W4383340940 creator A5010534419 @default.
- W4383340940 creator A5014010713 @default.
- W4383340940 creator A5015598139 @default.
- W4383340940 creator A5016302235 @default.
- W4383340940 creator A5017201727 @default.
- W4383340940 creator A5025949869 @default.
- W4383340940 creator A5026698381 @default.
- W4383340940 creator A5028122881 @default.
- W4383340940 creator A5040113035 @default.
- W4383340940 creator A5047441210 @default.
- W4383340940 creator A5047986978 @default.
- W4383340940 creator A5049303042 @default.
- W4383340940 creator A5056879660 @default.
- W4383340940 creator A5057277193 @default.
- W4383340940 creator A5061531314 @default.
- W4383340940 creator A5066637727 @default.
- W4383340940 creator A5067231808 @default.
- W4383340940 creator A5079918191 @default.
- W4383340940 creator A5089693509 @default.
- W4383340940 creator A5090756369 @default.
- W4383340940 date "2023-07-06" @default.
- W4383340940 modified "2023-10-09" @default.
- W4383340940 title "Alterations in the hepatocyte epigenetic landscape in steatosis" @default.
- W4383340940 cites W1900337607 @default.
- W4383340940 cites W1970208448 @default.
- W4383340940 cites W1973842058 @default.
- W4383340940 cites W1998081328 @default.
- W4383340940 cites W2022104878 @default.
- W4383340940 cites W2023535895 @default.
- W4383340940 cites W2030017268 @default.
- W4383340940 cites W2031792869 @default.
- W4383340940 cites W2033188250 @default.
- W4383340940 cites W2039053594 @default.
- W4383340940 cites W2043839229 @default.
- W4383340940 cites W2053521594 @default.
- W4383340940 cites W2061098901 @default.
- W4383340940 cites W2076154138 @default.
- W4383340940 cites W2079361407 @default.
- W4383340940 cites W2093637273 @default.
- W4383340940 cites W2108664168 @default.
- W4383340940 cites W2112484474 @default.
- W4383340940 cites W2114104545 @default.
- W4383340940 cites W2127196115 @default.
- W4383340940 cites W2128402823 @default.
- W4383340940 cites W2128505445 @default.
- W4383340940 cites W2133046153 @default.
- W4383340940 cites W2134520937 @default.
- W4383340940 cites W2136430672 @default.
- W4383340940 cites W2146512944 @default.
- W4383340940 cites W2150020322 @default.
- W4383340940 cites W2165102934 @default.
- W4383340940 cites W2166199493 @default.
- W4383340940 cites W2170552161 @default.
- W4383340940 cites W2222403319 @default.
- W4383340940 cites W2227252045 @default.
- W4383340940 cites W2513695655 @default.
- W4383340940 cites W2534149233 @default.
- W4383340940 cites W2558558963 @default.
- W4383340940 cites W2560311853 @default.
- W4383340940 cites W2582765547 @default.
- W4383340940 cites W2599102161 @default.
- W4383340940 cites W2606865793 @default.
- W4383340940 cites W2737507573 @default.
- W4383340940 cites W2752687869 @default.
- W4383340940 cites W2768013244 @default.
- W4383340940 cites W2772862192 @default.
- W4383340940 cites W2781850233 @default.
- W4383340940 cites W2785193639 @default.
- W4383340940 cites W2896364049 @default.
- W4383340940 cites W2900569176 @default.
- W4383340940 cites W2938759794 @default.
- W4383340940 cites W2944545583 @default.
- W4383340940 cites W2965113385 @default.
- W4383340940 cites W3000735920 @default.
- W4383340940 cites W3004644667 @default.
- W4383340940 cites W3012081632 @default.
- W4383340940 cites W3017465316 @default.
- W4383340940 cites W3025747175 @default.
- W4383340940 cites W3048420814 @default.
- W4383340940 cites W3110183739 @default.
- W4383340940 cites W3111061871 @default.
- W4383340940 cites W3180909105 @default.
- W4383340940 cites W3195323492 @default.
- W4383340940 cites W3195602324 @default.
- W4383340940 cites W4200408214 @default.
- W4383340940 cites W4205592486 @default.
- W4383340940 cites W4213098935 @default.
- W4383340940 cites W4221129079 @default.
- W4383340940 cites W4283796631 @default.
- W4383340940 cites W4293172929 @default.
- W4383340940 cites W4362465685 @default.
- W4383340940 doi "https://doi.org/10.1186/s13072-023-00504-8" @default.
- W4383340940 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37415213" @default.
- W4383340940 hasPublicationYear "2023" @default.
- W4383340940 type Work @default.