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- W4383341350 endingPage "224225" @default.
- W4383341350 startingPage "ard" @default.
- W4383341350 abstract "Recent technological progress has greatly advanced our understanding of human immunology. In particular, the discovery of human T follicular helper (Tfh) and T peripheral helper (Tph) cells has significantly advanced our understanding of human adaptive immune system. Tfh and Tph cells share similar molecular characteristics and both play critical roles in B cell differentiation and maturation. However, they differ in their functional properties, such as chemokine receptor expression and cytokine production. As a result, Tfh cells are mainly involved in B cell differentiation and maturation in germinal centres of secondary lymphoid tissues, while Tph cells are involved in B cell differentiation and tissue damage in peripheral inflammatory lesions. Importantly, the involvement of Tfh and Tph cells in the pathogenesis of rheumatic and musculoskeletal diseases has become clear. In rheumatoid arthritis and systemic lupus erythematosus, Tph cell infiltration is predominant in peripheral inflammatory lesions, whereas Tfh cell infiltration is predominant in the affected lesions of IgG4-related disease. Therefore, the contribution of Tfh and Tph cells to the development of rheumatic and musculoskeletal diseases varies depending on each disease. In this review, we provide an overview of human Tfh and Tph cells and summarise the latest findings on these novel T cell subsets in various rheumatic and musculoskeletal diseases." @default.
- W4383341350 created "2023-07-07" @default.
- W4383341350 creator A5027112607 @default.
- W4383341350 creator A5039165431 @default.
- W4383341350 creator A5040489632 @default.
- W4383341350 creator A5079477198 @default.
- W4383341350 date "2023-07-06" @default.
- W4383341350 modified "2023-10-14" @default.
- W4383341350 title "T follicular helper cells and T peripheral helper cells in rheumatic and musculoskeletal diseases" @default.
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