Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383342038> ?p ?o ?g. }
- W4383342038 abstract "The extracellular matrix (ECM) is a critical determinant of tumor fate that reflects the output from myriad cell types in the tumor. Collagens constitute the principal components of the tumor ECM. The changing collagen composition in tumors along with their impact on patient outcomes and possible biomarkers remains largely unknown. The RNA expression of the 43 collagen genes from solid tumors in The Cancer Genome Atlas (TCGA) was clustered to classify tumors. PanCancer analysis revealed how collagens by themselves can identify the tissue of origin. Clustering by collagens in each cancer type demonstrated strong associations with survival, specific immunoenvironments, somatic gene mutations, copy number variations, and aneuploidy. We developed a machine learning classifier that predicts aneuploidy, and chromosome arm copy number alteration (CNA) status based on collagen expression alone with high accuracy in many cancer types with somatic mutations, suggesting a strong relationship between the collagen ECM context and specific molecular alterations. These findings have broad implications in defining the relationship between cancer-related genetic defects and the tumor microenvironment to improve prognosis and therapeutic targeting for patient care, opening new avenues of investigation to define tumor ecosystems." @default.
- W4383342038 created "2023-07-07" @default.
- W4383342038 creator A5025774459 @default.
- W4383342038 creator A5048946015 @default.
- W4383342038 date "2023-07-06" @default.
- W4383342038 modified "2023-09-27" @default.
- W4383342038 title "Tumor collagens predict genetic features and patient outcomes" @default.
- W4383342038 cites W1760215417 @default.
- W4383342038 cites W1977764675 @default.
- W4383342038 cites W1980339876 @default.
- W4383342038 cites W1987865289 @default.
- W4383342038 cites W2018237806 @default.
- W4383342038 cites W2023906705 @default.
- W4383342038 cites W2047373299 @default.
- W4383342038 cites W2057179294 @default.
- W4383342038 cites W2065019315 @default.
- W4383342038 cites W2071949631 @default.
- W4383342038 cites W2086180233 @default.
- W4383342038 cites W2099618765 @default.
- W4383342038 cites W2108582427 @default.
- W4383342038 cites W2115124692 @default.
- W4383342038 cites W2123696077 @default.
- W4383342038 cites W2123879591 @default.
- W4383342038 cites W2149441684 @default.
- W4383342038 cites W2160075959 @default.
- W4383342038 cites W2324126234 @default.
- W4383342038 cites W2340064377 @default.
- W4383342038 cites W2467519122 @default.
- W4383342038 cites W2511694260 @default.
- W4383342038 cites W2730083492 @default.
- W4383342038 cites W2748710555 @default.
- W4383342038 cites W2752942423 @default.
- W4383342038 cites W2758173690 @default.
- W4383342038 cites W2794919347 @default.
- W4383342038 cites W2795441313 @default.
- W4383342038 cites W2796153844 @default.
- W4383342038 cites W2796207838 @default.
- W4383342038 cites W2796997430 @default.
- W4383342038 cites W2805688472 @default.
- W4383342038 cites W2883603086 @default.
- W4383342038 cites W2900958958 @default.
- W4383342038 cites W2925340929 @default.
- W4383342038 cites W2927324400 @default.
- W4383342038 cites W2932503900 @default.
- W4383342038 cites W2933409730 @default.
- W4383342038 cites W2937491450 @default.
- W4383342038 cites W2952280304 @default.
- W4383342038 cites W2972979814 @default.
- W4383342038 cites W2973350525 @default.
- W4383342038 cites W3005424744 @default.
- W4383342038 cites W3011519781 @default.
- W4383342038 cites W3107611031 @default.
- W4383342038 cites W3119400275 @default.
- W4383342038 cites W3129301541 @default.
- W4383342038 cites W3133960398 @default.
- W4383342038 cites W3134999753 @default.
- W4383342038 cites W3152583876 @default.
- W4383342038 cites W3209984193 @default.
- W4383342038 cites W4200579603 @default.
- W4383342038 cites W4220658740 @default.
- W4383342038 cites W4221020789 @default.
- W4383342038 cites W4243530926 @default.
- W4383342038 cites W4283395547 @default.
- W4383342038 doi "https://doi.org/10.1038/s41525-023-00358-9" @default.
- W4383342038 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37414817" @default.
- W4383342038 hasPublicationYear "2023" @default.
- W4383342038 type Work @default.
- W4383342038 citedByCount "0" @default.
- W4383342038 crossrefType "journal-article" @default.
- W4383342038 hasAuthorship W4383342038A5025774459 @default.
- W4383342038 hasAuthorship W4383342038A5048946015 @default.
- W4383342038 hasBestOaLocation W43833420381 @default.
- W4383342038 hasConcept C104317684 @default.
- W4383342038 hasConcept C121608353 @default.
- W4383342038 hasConcept C134305767 @default.
- W4383342038 hasConcept C151730666 @default.
- W4383342038 hasConcept C189165786 @default.
- W4383342038 hasConcept C2776107976 @default.
- W4383342038 hasConcept C2779256057 @default.
- W4383342038 hasConcept C2779343474 @default.
- W4383342038 hasConcept C2779672484 @default.
- W4383342038 hasConcept C30481170 @default.
- W4383342038 hasConcept C502942594 @default.
- W4383342038 hasConcept C54355233 @default.
- W4383342038 hasConcept C86803240 @default.
- W4383342038 hasConceptScore W4383342038C104317684 @default.
- W4383342038 hasConceptScore W4383342038C121608353 @default.
- W4383342038 hasConceptScore W4383342038C134305767 @default.
- W4383342038 hasConceptScore W4383342038C151730666 @default.
- W4383342038 hasConceptScore W4383342038C189165786 @default.
- W4383342038 hasConceptScore W4383342038C2776107976 @default.
- W4383342038 hasConceptScore W4383342038C2779256057 @default.
- W4383342038 hasConceptScore W4383342038C2779343474 @default.
- W4383342038 hasConceptScore W4383342038C2779672484 @default.
- W4383342038 hasConceptScore W4383342038C30481170 @default.
- W4383342038 hasConceptScore W4383342038C502942594 @default.
- W4383342038 hasConceptScore W4383342038C54355233 @default.
- W4383342038 hasConceptScore W4383342038C86803240 @default.
- W4383342038 hasIssue "1" @default.
- W4383342038 hasLocation W43833420381 @default.