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- W4383342255 endingPage "9576" @default.
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- W4383342255 abstract "Nucleosides have important therapeutic applications that include antiviral activities against COVID viruses. It is a common strategy to convert one or multiple of the hydroxyl (OH) units in nucleosides to the corresponding ester groups to prepare nucleoside prodrugs for better performance. Due to the presence of multiple OH units in nucleosides, current protocols for access to such ester prodrugs involve multiple steps due to installation and removal of protection groups. Here, we disclose a catalytic strategy that allows for regioselective functionalization of a specific OH unit without the need of protecting other OH groups. The key step in our method is an N-heterocyclic carbene-catalyzed selective acylation of the pentose unit of nucleosides. We demonstrate that commercially launched COVID-19 prodrugs such as molnupiravir can be prepared in concise routes by using our strategy." @default.
- W4383342255 created "2023-07-07" @default.
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- W4383342255 date "2023-07-06" @default.
- W4383342255 modified "2023-10-15" @default.
- W4383342255 title "Catalytic Regioselective Acylation of Unprotected Nucleosides for Quick Access to COVID and Other Nucleoside Prodrugs" @default.
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- W4383342255 doi "https://doi.org/10.1021/acscatal.3c02069" @default.
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