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- W4383368959 abstract "Super-enhancers are large, densely concentrated swaths of enhancers that regulate genes critical for cell identity. Tumorigenesis is accompanied by changes in the super-enhancer landscape. These aberrant super-enhancers commonly form to activate proto-oncogenes, or other genes upon which cancer cells depend, that initiate tumorigenesis, promote tumor proliferation, and increase the fitness of cancer cells to survive in the tumor microenvironment. These include well-recognized master regulators of proliferation in the setting of cancer, such as the transcription factor MYC which is under the control of numerous super-enhancers gained in cancer compared to normal tissues. This Review will cover the expanding cell-intrinsic and cell-extrinsic etiology of these super-enhancer changes in cancer, including somatic mutations, copy number variation, fusion events, extrachromosomal DNA, and 3D chromatin architecture, as well as those activated by inflammation, extra-cellular signaling, and the tumor microenvironment." @default.
- W4383368959 created "2023-07-07" @default.
- W4383368959 creator A5031180966 @default.
- W4383368959 creator A5082690187 @default.
- W4383368959 date "2023-07-06" @default.
- W4383368959 modified "2023-10-09" @default.
- W4383368959 title "Etiology of super-enhancer reprogramming and activation in cancer" @default.
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