Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383371464> ?p ?o ?g. }
- W4383371464 abstract "We celebrate this year the 50th anniversary of the first electrophysiological recordings of the gating currents from voltage-dependent ion channels done in 1973. This retrospective tries to illustrate the context knowledge on channel gating and the impact gating-current recording had then, and how it continued to clarify concepts, elaborate new ideas, and steer the scientific debate in these 50 years. The notion of gating particles and gating currents was first put forward by Hodgkin and Huxley in 1952 as a necessary assumption for interpreting the voltage dependence of the Na and K conductances of the action potential. 20 years later, gating currents were actually recorded, and over the following decades have represented the most direct means of tracing the movement of the gating charges and gaining insights into the mechanisms of channel gating. Most work in the early years was focused on the gating currents from the Na and K channels as found in the squid giant axon. With channel cloning and expression on heterologous systems, other channels as well as voltage-dependent enzymes were investigated. Other approaches were also introduced (cysteine mutagenesis and labeling, site-directed fluorometry, cryo-EM crystallography, and molecular dynamics [MD] modeling) to provide an integrated and coherent view of voltage-dependent gating in biological macromolecules. The layout of this retrospective reflects the past 50 years of investigations on gating currents, first addressing studies done on Na and K channels and then on other voltage-gated channels and non-channel structures. The review closes with a brief overview of how the gating-charge/voltage-sensor movements are translated into pore opening and the pathologies associated with mutations targeting the structures involved with the gating currents." @default.
- W4383371464 created "2023-07-07" @default.
- W4383371464 creator A5008957187 @default.
- W4383371464 creator A5024743606 @default.
- W4383371464 creator A5074239495 @default.
- W4383371464 date "2023-07-06" @default.
- W4383371464 modified "2023-09-26" @default.
- W4383371464 title "Fifty years of gating currents and channel gating" @default.
- W4383371464 cites W1524412093 @default.
- W4383371464 cites W1533488243 @default.
- W4383371464 cites W1576505582 @default.
- W4383371464 cites W1583298558 @default.
- W4383371464 cites W1589255772 @default.
- W4383371464 cites W1627770206 @default.
- W4383371464 cites W170944865 @default.
- W4383371464 cites W1947481567 @default.
- W4383371464 cites W1965191256 @default.
- W4383371464 cites W1966667742 @default.
- W4383371464 cites W1967176597 @default.
- W4383371464 cites W1967798714 @default.
- W4383371464 cites W1969129798 @default.
- W4383371464 cites W1969708254 @default.
- W4383371464 cites W1970264142 @default.
- W4383371464 cites W1972459374 @default.
- W4383371464 cites W1973064936 @default.
- W4383371464 cites W1973150566 @default.
- W4383371464 cites W1974411391 @default.
- W4383371464 cites W1974643631 @default.
- W4383371464 cites W1975202593 @default.
- W4383371464 cites W1975537381 @default.
- W4383371464 cites W1976359893 @default.
- W4383371464 cites W1977083578 @default.
- W4383371464 cites W1978195452 @default.
- W4383371464 cites W1978299298 @default.
- W4383371464 cites W1978494722 @default.
- W4383371464 cites W1980404699 @default.
- W4383371464 cites W1980619085 @default.
- W4383371464 cites W1981928447 @default.
- W4383371464 cites W1982505565 @default.
- W4383371464 cites W1983187084 @default.
- W4383371464 cites W1983519301 @default.
- W4383371464 cites W1983520523 @default.
- W4383371464 cites W1983523125 @default.
- W4383371464 cites W1983704513 @default.
- W4383371464 cites W1985248774 @default.
- W4383371464 cites W1985295342 @default.
- W4383371464 cites W1985940938 @default.
- W4383371464 cites W1986172439 @default.
- W4383371464 cites W1986361578 @default.
- W4383371464 cites W1987199597 @default.
- W4383371464 cites W1987493270 @default.
- W4383371464 cites W1989585015 @default.
- W4383371464 cites W1990323937 @default.
- W4383371464 cites W1996437700 @default.
- W4383371464 cites W1998916678 @default.
- W4383371464 cites W1999932376 @default.
- W4383371464 cites W2000054304 @default.
- W4383371464 cites W2000181571 @default.
- W4383371464 cites W2000670424 @default.
- W4383371464 cites W2004073251 @default.
- W4383371464 cites W2004079359 @default.
- W4383371464 cites W2007933399 @default.
- W4383371464 cites W2008002200 @default.
- W4383371464 cites W2008100921 @default.
- W4383371464 cites W2008470626 @default.
- W4383371464 cites W2009518885 @default.
- W4383371464 cites W2010690165 @default.
- W4383371464 cites W2010894079 @default.
- W4383371464 cites W2011424443 @default.
- W4383371464 cites W2012422753 @default.
- W4383371464 cites W2013988104 @default.
- W4383371464 cites W2014799719 @default.
- W4383371464 cites W2015268846 @default.
- W4383371464 cites W2017708614 @default.
- W4383371464 cites W2018527368 @default.
- W4383371464 cites W2019421760 @default.
- W4383371464 cites W2020448043 @default.
- W4383371464 cites W2020537292 @default.
- W4383371464 cites W2022790697 @default.
- W4383371464 cites W2024929666 @default.
- W4383371464 cites W2025385677 @default.
- W4383371464 cites W2026823182 @default.
- W4383371464 cites W2027551150 @default.
- W4383371464 cites W2028171456 @default.
- W4383371464 cites W2029256174 @default.
- W4383371464 cites W2029592445 @default.
- W4383371464 cites W2033080277 @default.
- W4383371464 cites W2033689106 @default.
- W4383371464 cites W2034026790 @default.
- W4383371464 cites W2034352765 @default.
- W4383371464 cites W2035066043 @default.
- W4383371464 cites W2036937904 @default.
- W4383371464 cites W2037048489 @default.
- W4383371464 cites W2038321772 @default.
- W4383371464 cites W2038687737 @default.
- W4383371464 cites W2039010435 @default.
- W4383371464 cites W2039757506 @default.
- W4383371464 cites W2040016078 @default.
- W4383371464 cites W2040826404 @default.
- W4383371464 cites W2041241955 @default.