Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383371471> ?p ?o ?g. }
Showing items 1 to 100 of
100
with 100 items per page.
- W4383371471 abstract "Background Acetaminophen is utilized in human infants for pain management and fever. Neonatal foals might benefit from administration of acetaminophen but effective and safe dosage regimens for neonatal foals remains to be determined. Objective The objective was to determine the plasma pharmacokinetics of acetaminophen following oral administration of a single dose of 20 mg/kg or 40 mg/kg to neonatal foals. A secondary objective was to evaluate any changes in hematology and biochemistry profiles. Study design Randomized study. Methods Eight clinically healthy 7–9-day old Quarter Horse foals (3 colts and 5 fillies) received a single oral dose of acetaminophen either 20 ( n = 4) or 40 ( n = 4) mg/kg. Hematology and biochemistry profiles were evaluated before and 7 days after drug administration. Blood samples were collected before and 8 times after acetaminophen administration for 48 h to quantify plasma acetaminophen concentrations. Plasma pharmacokinetic parameters were estimated using non- compartmental analysis. Results The median peak plasma concentrations (and range) occurred at 1.5 (0.5–2) hours, and 1.0 (1–2) hours for the 20 and 40 mg/kg doses. The maximum plasma concentration (and range) was 12 (7.9–17.4) μg/mL for the 20 mg/kg dose and 14 (11–18) μg/mL for 40 mg/kg dose. The median AUC 0-∞ ranged from 46 to 100 and 79 to 160 h*-μg/mL for the 20 and 40 mg/kg dose, respectively. Hematology and biochemistry profiles remained within normal limits. Conclusion Plasma disposition of acetaminophen after oral administration of 20 and 40 mg/kg to neonates is comparable to adult horses. However, safety and the optimal dosage regimen of acetaminophen for treating pain and or pyrexia in neonates in this age group remains to be determined." @default.
- W4383371471 created "2023-07-07" @default.
- W4383371471 creator A5026454268 @default.
- W4383371471 creator A5032623688 @default.
- W4383371471 creator A5033215111 @default.
- W4383371471 creator A5086320712 @default.
- W4383371471 date "2023-07-06" @default.
- W4383371471 modified "2023-09-26" @default.
- W4383371471 title "Pharmacokinetics of acetaminophen after a single Oral administration of 20 or 40 mg/kg to 7–9 Day-old foals" @default.
- W4383371471 cites W177722852 @default.
- W4383371471 cites W1931708045 @default.
- W4383371471 cites W1957718823 @default.
- W4383371471 cites W1977430378 @default.
- W4383371471 cites W1988022616 @default.
- W4383371471 cites W2008839228 @default.
- W4383371471 cites W2015503275 @default.
- W4383371471 cites W2036029912 @default.
- W4383371471 cites W2044920061 @default.
- W4383371471 cites W2045632847 @default.
- W4383371471 cites W2047173081 @default.
- W4383371471 cites W2052252521 @default.
- W4383371471 cites W2064492513 @default.
- W4383371471 cites W2067570070 @default.
- W4383371471 cites W2067845278 @default.
- W4383371471 cites W2102007706 @default.
- W4383371471 cites W2112192018 @default.
- W4383371471 cites W2124677775 @default.
- W4383371471 cites W2147433746 @default.
- W4383371471 cites W2150359313 @default.
- W4383371471 cites W2152220240 @default.
- W4383371471 cites W2169884177 @default.
- W4383371471 cites W2175489491 @default.
- W4383371471 cites W2402000540 @default.
- W4383371471 cites W2417546777 @default.
- W4383371471 cites W2461975652 @default.
- W4383371471 cites W2474552610 @default.
- W4383371471 cites W29037222 @default.
- W4383371471 cites W2912133320 @default.
- W4383371471 cites W2924426707 @default.
- W4383371471 cites W3096052795 @default.
- W4383371471 cites W3111905213 @default.
- W4383371471 cites W3206216855 @default.
- W4383371471 cites W4281670291 @default.
- W4383371471 cites W4310956233 @default.
- W4383371471 cites W4379769405 @default.
- W4383371471 cites W973722855 @default.
- W4383371471 doi "https://doi.org/10.3389/fvets.2023.1198940" @default.
- W4383371471 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37483288" @default.
- W4383371471 hasPublicationYear "2023" @default.
- W4383371471 type Work @default.
- W4383371471 citedByCount "0" @default.
- W4383371471 crossrefType "journal-article" @default.
- W4383371471 hasAuthorship W4383371471A5026454268 @default.
- W4383371471 hasAuthorship W4383371471A5032623688 @default.
- W4383371471 hasAuthorship W4383371471A5033215111 @default.
- W4383371471 hasAuthorship W4383371471A5086320712 @default.
- W4383371471 hasBestOaLocation W43833714711 @default.
- W4383371471 hasConcept C112705442 @default.
- W4383371471 hasConcept C126322002 @default.
- W4383371471 hasConcept C151730666 @default.
- W4383371471 hasConcept C194409129 @default.
- W4383371471 hasConcept C2777056448 @default.
- W4383371471 hasConcept C2778722691 @default.
- W4383371471 hasConcept C2780762169 @default.
- W4383371471 hasConcept C3020079912 @default.
- W4383371471 hasConcept C42219234 @default.
- W4383371471 hasConcept C71924100 @default.
- W4383371471 hasConcept C86803240 @default.
- W4383371471 hasConcept C98274493 @default.
- W4383371471 hasConceptScore W4383371471C112705442 @default.
- W4383371471 hasConceptScore W4383371471C126322002 @default.
- W4383371471 hasConceptScore W4383371471C151730666 @default.
- W4383371471 hasConceptScore W4383371471C194409129 @default.
- W4383371471 hasConceptScore W4383371471C2777056448 @default.
- W4383371471 hasConceptScore W4383371471C2778722691 @default.
- W4383371471 hasConceptScore W4383371471C2780762169 @default.
- W4383371471 hasConceptScore W4383371471C3020079912 @default.
- W4383371471 hasConceptScore W4383371471C42219234 @default.
- W4383371471 hasConceptScore W4383371471C71924100 @default.
- W4383371471 hasConceptScore W4383371471C86803240 @default.
- W4383371471 hasConceptScore W4383371471C98274493 @default.
- W4383371471 hasLocation W43833714711 @default.
- W4383371471 hasLocation W43833714712 @default.
- W4383371471 hasLocation W43833714713 @default.
- W4383371471 hasOpenAccess W4383371471 @default.
- W4383371471 hasPrimaryLocation W43833714711 @default.
- W4383371471 hasRelatedWork W1573667742 @default.
- W4383371471 hasRelatedWork W1964074490 @default.
- W4383371471 hasRelatedWork W2001333918 @default.
- W4383371471 hasRelatedWork W2081448791 @default.
- W4383371471 hasRelatedWork W2090901580 @default.
- W4383371471 hasRelatedWork W2317627837 @default.
- W4383371471 hasRelatedWork W2331297863 @default.
- W4383371471 hasRelatedWork W2414263157 @default.
- W4383371471 hasRelatedWork W2431352314 @default.
- W4383371471 hasRelatedWork W2472211910 @default.
- W4383371471 hasVolume "10" @default.
- W4383371471 isParatext "false" @default.
- W4383371471 isRetracted "false" @default.
- W4383371471 workType "article" @default.