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- W4383373355 abstract "Sporadic Alzheimer's disease and cancer remain epidemiologically inversely related, and exploring the reverse pathogenesis is important for our understanding of both. Cognitive dysfunctions in Alzheimer's disease (AD) might result from the depletion of adaptive reserves in the brain. Energy storage in the brain is limited and is dynamically regulated by neurovascular and neurometabolic coupling. The research on neurodegenerative diseases has been dominated by the neurocentric view that neuronal defects cause the diseases. However, the proposal of the 2-hit vascular hypothesis in AD led us to focus on alterations in the vasculature, especially hypoperfusion. Chronic hypoxia is a feature shared by AD and cancer. It is interesting how contradicting chronic hypoxia's effects on both cancer and AD are. In this article, we discuss the potential links between the 2 diseases' etiology, from comparable upstream circumstances to diametrically opposed downstream effects. We suggest opposing potential mechanisms, including upregulation and downregulation of hypoxia-inducible factor-1α, the Warburg and reverse-Warburg effects, lactate-mediated intracellular acidic and alkaline conditions, and VDAC1-mediated apoptosis and antiapoptosis, and search for regulators that may be identified as the crossroads between cancer and AD." @default.
- W4383373355 created "2023-07-07" @default.
- W4383373355 creator A5025030665 @default.
- W4383373355 creator A5031969511 @default.
- W4383373355 creator A5032528993 @default.
- W4383373355 creator A5068349150 @default.
- W4383373355 date "2023-11-01" @default.
- W4383373355 modified "2023-10-03" @default.
- W4383373355 title "Inverse correlation between Alzheimer’s disease and cancer from the perspective of hypoxia" @default.
- W4383373355 cites W10325798 @default.
- W4383373355 cites W1530768309 @default.
- W4383373355 cites W1572656384 @default.
- W4383373355 cites W1685999671 @default.
- W4383373355 cites W1706021753 @default.
- W4383373355 cites W1877874306 @default.
- W4383373355 cites W1900793573 @default.
- W4383373355 cites W1959137333 @default.
- W4383373355 cites W1963757800 @default.
- W4383373355 cites W1964117773 @default.
- W4383373355 cites W1971285535 @default.
- W4383373355 cites W1972414420 @default.
- W4383373355 cites W1972776675 @default.
- W4383373355 cites W1974111128 @default.
- W4383373355 cites W1974124405 @default.
- W4383373355 cites W1975005283 @default.
- W4383373355 cites W1975661602 @default.
- W4383373355 cites W1977767943 @default.
- W4383373355 cites W1978139448 @default.
- W4383373355 cites W1980792888 @default.
- W4383373355 cites W1982795519 @default.
- W4383373355 cites W1983750588 @default.
- W4383373355 cites W1983819045 @default.
- W4383373355 cites W1984060145 @default.
- W4383373355 cites W1985994475 @default.
- W4383373355 cites W1986199954 @default.
- W4383373355 cites W1989528677 @default.
- W4383373355 cites W1990427131 @default.
- W4383373355 cites W1991421091 @default.
- W4383373355 cites W1992521533 @default.
- W4383373355 cites W1993160420 @default.
- W4383373355 cites W1996757064 @default.
- W4383373355 cites W1996830477 @default.
- W4383373355 cites W2003502313 @default.
- W4383373355 cites W2006382458 @default.
- W4383373355 cites W2009520960 @default.
- W4383373355 cites W2011829284 @default.
- W4383373355 cites W2012080020 @default.
- W4383373355 cites W2018288777 @default.
- W4383373355 cites W2018722597 @default.
- W4383373355 cites W2020993937 @default.
- W4383373355 cites W2022401741 @default.
- W4383373355 cites W2023217997 @default.
- W4383373355 cites W2023999138 @default.
- W4383373355 cites W2024706475 @default.
- W4383373355 cites W2024955728 @default.
- W4383373355 cites W2026509836 @default.
- W4383373355 cites W2028156849 @default.
- W4383373355 cites W2028372123 @default.
- W4383373355 cites W2029740608 @default.
- W4383373355 cites W2030333049 @default.
- W4383373355 cites W2031703986 @default.
- W4383373355 cites W2034664059 @default.
- W4383373355 cites W2037454422 @default.
- W4383373355 cites W2040490831 @default.
- W4383373355 cites W2046687522 @default.
- W4383373355 cites W2047195788 @default.
- W4383373355 cites W2050442786 @default.
- W4383373355 cites W2051064550 @default.
- W4383373355 cites W2052521178 @default.
- W4383373355 cites W2053797563 @default.
- W4383373355 cites W2054645758 @default.
- W4383373355 cites W2055852420 @default.
- W4383373355 cites W2059476598 @default.
- W4383373355 cites W2060629467 @default.
- W4383373355 cites W2060878129 @default.
- W4383373355 cites W2062967090 @default.
- W4383373355 cites W2063147924 @default.
- W4383373355 cites W2064235709 @default.
- W4383373355 cites W2066977609 @default.
- W4383373355 cites W2068050569 @default.
- W4383373355 cites W2072278357 @default.
- W4383373355 cites W2072902622 @default.
- W4383373355 cites W2084885101 @default.
- W4383373355 cites W2086733715 @default.
- W4383373355 cites W2086921112 @default.
- W4383373355 cites W2087624852 @default.
- W4383373355 cites W2087987630 @default.
- W4383373355 cites W2089390439 @default.
- W4383373355 cites W2091036612 @default.
- W4383373355 cites W2092800106 @default.
- W4383373355 cites W2095987251 @default.
- W4383373355 cites W2096258216 @default.
- W4383373355 cites W2097259163 @default.
- W4383373355 cites W2097463188 @default.
- W4383373355 cites W2097990780 @default.
- W4383373355 cites W2098685543 @default.
- W4383373355 cites W2100262552 @default.
- W4383373355 cites W2102140136 @default.