FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383373695> ?p ?o ?g. }

• W4383373695 endingPage "2023" @default.
• W4383373695 startingPage "00225" @default.
• W4383373695 abstract "The effects of prenatal antibiotic exposure on respiratory morbidity in infancy and the involved mechanisms are still poorly understood. We aimed to examine whether prenatal antibiotic exposure in the third trimester is associated with nasal microbiome and respiratory morbidity in infancy and at school age, and whether this association with respiratory morbidity is mediated by the nasal microbiome.We performed 16S ribosomal RNA gene sequencing (regions V3-V4) on nasal swabs obtained from 296 healthy term infants from the prospective Basel-Bern birth cohort (BILD) at age 4-6 weeks. Information about antibiotic exposure was derived from birth records and standardised interviews. Respiratory symptoms were assessed by weekly telephone interviews in the first year of life and a clinical visit at age 6 years. Structural equation modelling was used to test direct and indirect associations accounting for known risk factors.α-Diversity indices were lower in infants with antibiotic exposure compared to nonexposed infants (e.g. Shannon index p-value 0.006). Prenatal antibiotic exposure was also associated with a higher risk of any, as well as severe, respiratory symptoms in the first year of life (risk ratio 1.38, 95% CI 1.03-1.84; adjusted p-value (padj)=0.032 and risk ratio 1.75, 95% CI 1.02-2.97; padj=0.041, respectively), but not with wheeze or atopy in childhood. However, we found no indirect mediating effect of nasal microbiome explaining these clinical symptoms.Prenatal antibiotic exposure was associated with lower diversity of nasal microbiome in infancy and, independently of microbiome, with respiratory morbidity in infancy, but not with symptoms later in life." @default.
• W4383373695 created "2023-07-07" @default.
• W4383373695 creator A5022529558 @default.
• W4383373695 creator A5023263558 @default.
• W4383373695 creator A5027043694 @default.
• W4383373695 creator A5028016444 @default.
• W4383373695 creator A5033211270 @default.
• W4383373695 creator A5041555853 @default.
• W4383373695 creator A5041722589 @default.
• W4383373695 creator A5042718918 @default.
• W4383373695 creator A5054409333 @default.
• W4383373695 creator A5056030123 @default.
• W4383373695 creator A5060442315 @default.
• W4383373695 creator A5065695664 @default.
• W4383373695 creator A5066716165 @default.
• W4383373695 creator A5077475021 @default.
• W4383373695 creator A5089769013 @default.
• W4383373695 date "2023-07-01" @default.
• W4383373695 modified "2023-09-27" @default.
• W4383373695 title "Antibiotics in pregnancy influence nasal microbiome and respiratory morbidity in infancy" @default.
• W4383373695 cites W1528668937 @default.
• W4383373695 cites W1831022746 @default.
• W4383373695 cites W1907317140 @default.
• W4383373695 cites W1985140717 @default.
• W4383373695 cites W2057192777 @default.
• W4383373695 cites W2100589529 @default.
• W4383373695 cites W2100638692 @default.
• W4383373695 cites W2117617490 @default.
• W4383373695 cites W2126117556 @default.
• W4383373695 cites W2129823429 @default.
• W4383373695 cites W2135336683 @default.
• W4383373695 cites W2156778911 @default.
• W4383373695 cites W2179438025 @default.
• W4383373695 cites W2330357242 @default.
• W4383373695 cites W2346069395 @default.
• W4383373695 cites W2552221604 @default.
• W4383373695 cites W2727392759 @default.
• W4383373695 cites W2791116667 @default.
• W4383373695 cites W2889794943 @default.
• W4383373695 cites W2898752387 @default.
• W4383373695 cites W2901109989 @default.
• W4383373695 cites W2903246981 @default.
• W4383373695 cites W2943898598 @default.
• W4383373695 cites W2947965912 @default.
• W4383373695 cites W2990027255 @default.
• W4383373695 cites W3005900220 @default.
• W4383373695 cites W3012347472 @default.
• W4383373695 cites W3012464821 @default.
• W4383373695 cites W3014028877 @default.
• W4383373695 cites W3023538982 @default.
• W4383373695 cites W3029769264 @default.
• W4383373695 cites W3033433107 @default.
• W4383373695 cites W3093041539 @default.
• W4383373695 cites W3098744816 @default.
• W4383373695 cites W3127526240 @default.
• W4383373695 cites W3135073837 @default.
• W4383373695 cites W3185968025 @default.
• W4383373695 cites W4210841001 @default.
• W4383373695 cites W4242702784 @default.
• W4383373695 cites W4289779369 @default.
• W4383373695 doi "https://doi.org/10.1183/23120541.00225-2023" @default.
• W4383373695 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37650088" @default.
• W4383373695 hasPublicationYear "2023" @default.
• W4383373695 type Work @default.
• W4383373695 citedByCount "0" @default.
• W4383373695 crossrefType "journal-article" @default.
• W4383373695 hasAuthorship W4383373695A5022529558 @default.
• W4383373695 hasAuthorship W4383373695A5023263558 @default.
• W4383373695 hasAuthorship W4383373695A5027043694 @default.
• W4383373695 hasAuthorship W4383373695A5028016444 @default.
• W4383373695 hasAuthorship W4383373695A5033211270 @default.
• W4383373695 hasAuthorship W4383373695A5041555853 @default.
• W4383373695 hasAuthorship W4383373695A5041722589 @default.
• W4383373695 hasAuthorship W4383373695A5042718918 @default.
• W4383373695 hasAuthorship W4383373695A5054409333 @default.
• W4383373695 hasAuthorship W4383373695A5056030123 @default.
• W4383373695 hasAuthorship W4383373695A5060442315 @default.
• W4383373695 hasAuthorship W4383373695A5065695664 @default.
• W4383373695 hasAuthorship W4383373695A5066716165 @default.
• W4383373695 hasAuthorship W4383373695A5077475021 @default.
• W4383373695 hasAuthorship W4383373695A5089769013 @default.
• W4383373695 hasBestOaLocation W43833736951 @default.
• W4383373695 hasConcept C126322002 @default.
• W4383373695 hasConcept C131872663 @default.
• W4383373695 hasConcept C143121216 @default.
• W4383373695 hasConcept C187212893 @default.
• W4383373695 hasConcept C188816634 @default.
• W4383373695 hasConcept C201903717 @default.
• W4383373695 hasConcept C2776042228 @default.
• W4383373695 hasConcept C2777697326 @default.
• W4383373695 hasConcept C2778338976 @default.
• W4383373695 hasConcept C2779234561 @default.
• W4383373695 hasConcept C501593827 @default.
• W4383373695 hasConcept C534529494 @default.
• W4383373695 hasConcept C54355233 @default.
• W4383373695 hasConcept C60644358 @default.
• W4383373695 hasConcept C71924100 @default.
• W4383373695 hasConcept C72563966 @default.

• next