FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383374878> ?p ?o ?g. }

• W4383374878 abstract "Background Malignant glioma is the most common intracranial malignant tumor with the highest mortality. In the era of immunotherapy, it is important to determine what type of immunotherapy provides the best chance of survival. Method Here, the efficacy and safety of immunotherapy in high-grade glioma (HGG) were evaluated by systematic review and meta-analysis. The differences between various types of immunotherapy were explored. Retrieved hits were screened for inclusion in 2,317 articles. We extracted the overall survival (OS) and progression-free survival (PFS) hazard ratios (HRs) as two key outcomes for examining the efficacy of immunotherapy. We also analyzed data on the reported corresponding adverse events to assess the safety of immunotherapy. This study was registered with PROSPERO (CRD42019112356). Results We included a total of 1,271 patients, of which 524 received a combination of immunotherapy and standard of care (SOC), while 747 received SOC alone. We found that immunotherapy extended the OS (HR = 0.74; 95% confidence interval [CI], 0.56−0.99; Z = −2.00, P = 0.0458 &lt; 0.05) and PFS (HR = 0.67; 95% CI, 0.45−0.99; Z = −1.99, P = 0.0466 &lt; 0.05), although certain adverse events occurred (proportion = 0.0773, 95% CI, 0.0589-0.1014). Our data have demonstrated the efficacy of the dendritic cell (DC) vaccine in prolonging the OS (HR = 0.38; 95% CI, 0.21−0.68; Z = −3.23; P = 0.0012 &lt; 0.05) of glioma patients. Oncolytic viral therapy (VT) only extended patient survival in a subgroup analysis (HR = 0.60; 95% CI, 0.45−0.80; Z = −3.53; P = 0.0004 &lt; 0.05). By contrast, immunopotentiation (IP) did not prolong OS (HR = 0.69; 95% CI, 0.50−0.96; Z = −2.23; P = 0.0256). Conclusion Thus, DC vaccination significantly prolonged the OS of HGG patients, however, the efficacy of VT and IP should be explored in further studies. All the therapeutic schemes evaluated were associated with certain side effects. Systematic review registration https://www.crd.york.ac.uk/PROSPERO/display_record.php?RecordID=112356 ." @default.
• W4383374878 created "2023-07-07" @default.
• W4383374878 creator A5012280419 @default.
• W4383374878 creator A5024034790 @default.
• W4383374878 creator A5033559321 @default.
• W4383374878 creator A5041992809 @default.
• W4383374878 creator A5043769936 @default.
• W4383374878 creator A5053422742 @default.
• W4383374878 creator A5055200243 @default.
• W4383374878 creator A5074655720 @default.
• W4383374878 date "2023-07-06" @default.
• W4383374878 modified "2023-10-14" @default.
• W4383374878 title "Efficacy and safety of innate and adaptive immunotherapy combined with standard of care in high-grade gliomas: a systematic review and meta-analysis" @default.
• W4383374878 cites W1507541460 @default.
• W4383374878 cites W1598602811 @default.
• W4383374878 cites W1828443506 @default.
• W4383374878 cites W1930332244 @default.
• W4383374878 cites W1986974008 @default.
• W4383374878 cites W1995055770 @default.
• W4383374878 cites W1995121009 @default.
• W4383374878 cites W2049309316 @default.
• W4383374878 cites W2054179916 @default.
• W4383374878 cites W2058836795 @default.
• W4383374878 cites W2083172345 @default.
• W4383374878 cites W2096555449 @default.
• W4383374878 cites W2097478662 @default.
• W4383374878 cites W2097965368 @default.
• W4383374878 cites W2100004531 @default.
• W4383374878 cites W2104951898 @default.
• W4383374878 cites W2107803747 @default.
• W4383374878 cites W2116583846 @default.
• W4383374878 cites W2129387595 @default.
• W4383374878 cites W2148977460 @default.
• W4383374878 cites W2159423482 @default.
• W4383374878 cites W2161419307 @default.
• W4383374878 cites W2172477250 @default.
• W4383374878 cites W2209618509 @default.
• W4383374878 cites W2304124491 @default.
• W4383374878 cites W2567424265 @default.
• W4383374878 cites W2575232561 @default.
• W4383374878 cites W2580803528 @default.
• W4383374878 cites W2605626471 @default.
• W4383374878 cites W2738678436 @default.
• W4383374878 cites W2749025438 @default.
• W4383374878 cites W2788975052 @default.
• W4383374878 cites W2796584001 @default.
• W4383374878 cites W2803369586 @default.
• W4383374878 cites W2805359783 @default.
• W4383374878 cites W2811300508 @default.
• W4383374878 cites W2887576254 @default.
• W4383374878 cites W2888273332 @default.
• W4383374878 cites W2889295047 @default.
• W4383374878 cites W2911871569 @default.
• W4383374878 cites W2913623258 @default.
• W4383374878 cites W2968318393 @default.
• W4383374878 cites W2989877647 @default.
• W4383374878 cites W3004467467 @default.
• W4383374878 cites W3005468192 @default.
• W4383374878 cites W3011268210 @default.
• W4383374878 cites W3013850623 @default.
• W4383374878 cites W3026551532 @default.
• W4383374878 cites W3106005610 @default.
• W4383374878 cites W3126772665 @default.
• W4383374878 cites W3174246647 @default.
• W4383374878 cites W3188411100 @default.
• W4383374878 cites W3203575974 @default.
• W4383374878 cites W3206733738 @default.
• W4383374878 cites W4212862326 @default.
• W4383374878 cites W4212964281 @default.
• W4383374878 cites W4214816481 @default.
• W4383374878 cites W4245392732 @default.
• W4383374878 cites W4286492761 @default.
• W4383374878 cites W4292117589 @default.
• W4383374878 cites W4297399721 @default.
• W4383374878 cites W4309183974 @default.
• W4383374878 doi "https://doi.org/10.3389/fimmu.2023.966696" @default.
• W4383374878 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37483593" @default.
• W4383374878 hasPublicationYear "2023" @default.
• W4383374878 type Work @default.
• W4383374878 citedByCount "0" @default.
• W4383374878 crossrefType "journal-article" @default.
• W4383374878 hasAuthorship W4383374878A5012280419 @default.
• W4383374878 hasAuthorship W4383374878A5024034790 @default.
• W4383374878 hasAuthorship W4383374878A5033559321 @default.
• W4383374878 hasAuthorship W4383374878A5041992809 @default.
• W4383374878 hasAuthorship W4383374878A5043769936 @default.
• W4383374878 hasAuthorship W4383374878A5053422742 @default.
• W4383374878 hasAuthorship W4383374878A5055200243 @default.
• W4383374878 hasAuthorship W4383374878A5074655720 @default.
• W4383374878 hasBestOaLocation W43833748781 @default.
• W4383374878 hasConcept C121608353 @default.
• W4383374878 hasConcept C126322002 @default.
• W4383374878 hasConcept C143998085 @default.
• W4383374878 hasConcept C197934379 @default.
• W4383374878 hasConcept C207103383 @default.
• W4383374878 hasConcept C2777701055 @default.
• W4383374878 hasConcept C2778227246 @default.
• W4383374878 hasConcept C2993769353 @default.
• W4383374878 hasConcept C44249647 @default.
• W4383374878 hasConcept C502942594 @default.

• next