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- W4383375803 abstract "Abstract In this paper, a class of virus-to-cell HIV model with intracellular delays, saturated incidence and Logistic growth is proposed to characterize the interaction between two types HIV strains, i.e., wild-type and drug-resistant strains. First, a series of threshold criteria on the locally and globally asymptotic stability of (infection-free, dominant, coexistence) equilibria are discussed based on the basic reproduction number $R_0$. Furthermore, a detailed Hopf bifurcation analysis is performed on the coexistence equilibrium using two delays as bifurcation parameters. We find that the Hopf bifurcations induced by double-strains are evidently different and more complicated than single strain, the former switches from stability (periodic branches) to un-stability (chaos) more frequent and earlier than the latter since double-strains would yield more pairs of imaginary roots in the characteristic equations. Meanwhile, the total viral load of double-strains would be higher than that of single-strain as well. The emergence of drug resistance imposes either negative or positive influences on the survival of wild-type strain, which would further facilitate the transmission of HIV." @default.
- W4383375803 created "2023-07-07" @default.
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- W4383375803 date "2023-07-06" @default.
- W4383375803 modified "2023-09-27" @default.
- W4383375803 title "Bifurcation analysis and chaos for a double-strains HIV coinfection model with intracellular delays, saturated incidence and Logistic growth" @default.
- W4383375803 doi "https://doi.org/10.21203/rs.3.rs-3132841/v1" @default.
- W4383375803 hasPublicationYear "2023" @default.
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