FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383375939> ?p ?o ?g. }

• W4383375939 endingPage "137363" @default.
• W4383375939 startingPage "137363" @default.
• W4383375939 abstract "The deregulated spinal cord proteins induced by nerve injury are the key to neuropathic pain. Integrated transcriptome and translatome analyses can screen out deregulated proteins controlled by only post-transcriptional regulation. By comparing RNA sequencing (RNA-seq) and ribosome profiling sequencing (Ribo-seq) data, we identified an upregulated protein, chromobox 2 (CBX2), with its mRNA level unchanged in the spinal cord after peripheral nerve injury. CBX2 was mainly distributed in the spinal cord neurons. Blocking the SNL-induced increase of spinal CBX2 attenuated the neuronal and astrocytes hyperactivities and pain hypersensitivities in both the development and maintenance phases. Conversely, mimicking the upregulation of CBX2 in the spinal cord facilitated the activities of neurons and astrocytes and produced evoked nociceptive hypersensitivity and spontaneous pain. Our results also revealed that activating the ERK pathway, upregulating CXCL13 in neurons, and CXCL13 further inducing astrocyte activation were possible downstream signaling mechanisms of CBX2 in pain processing. In conclusion, upregulation of CBX2 after nerve injury leads to nociceptive hyperalgesia by promoting neuronal and astrocyte hyperactivities through the ERK pathway. Inhibiting CBX2 upregulation may be therapeutically beneficial." @default.
• W4383375939 created "2023-07-07" @default.
• W4383375939 creator A5004000135 @default.
• W4383375939 creator A5012845876 @default.
• W4383375939 creator A5020398012 @default.
• W4383375939 creator A5023900529 @default.
• W4383375939 creator A5033684035 @default.
• W4383375939 creator A5037543576 @default.
• W4383375939 creator A5041780665 @default.
• W4383375939 creator A5053447705 @default.
• W4383375939 creator A5056967074 @default.
• W4383375939 creator A5069906360 @default.
• W4383375939 creator A5074695060 @default.
• W4383375939 creator A5082664098 @default.
• W4383375939 creator A5085530541 @default.
• W4383375939 date "2023-08-01" @default.
• W4383375939 modified "2023-09-22" @default.
• W4383375939 title "Spinal CBX2 contributes to neuropathic pain by activating ERK signaling pathway in male mice" @default.
• W4383375939 cites W1971915141 @default.
• W4383375939 cites W2006161356 @default.
• W4383375939 cites W2025553576 @default.
• W4383375939 cites W2066796908 @default.
• W4383375939 cites W2124486107 @default.
• W4383375939 cites W2163106706 @default.
• W4383375939 cites W2175136759 @default.
• W4383375939 cites W2202702753 @default.
• W4383375939 cites W2234168863 @default.
• W4383375939 cites W2293225266 @default.
• W4383375939 cites W2412491965 @default.
• W4383375939 cites W2475088686 @default.
• W4383375939 cites W2546967042 @default.
• W4383375939 cites W2793212576 @default.
• W4383375939 cites W2793991924 @default.
• W4383375939 cites W2799815882 @default.
• W4383375939 cites W2910729187 @default.
• W4383375939 cites W3026041669 @default.
• W4383375939 cites W3081863552 @default.
• W4383375939 cites W3127140056 @default.
• W4383375939 cites W3211684109 @default.
• W4383375939 cites W4282914444 @default.
• W4383375939 cites W4282939944 @default.
• W4383375939 cites W4362521028 @default.
• W4383375939 doi "https://doi.org/10.1016/j.neulet.2023.137363" @default.
• W4383375939 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37422020" @default.
• W4383375939 hasPublicationYear "2023" @default.
• W4383375939 type Work @default.
• W4383375939 citedByCount "0" @default.
• W4383375939 crossrefType "journal-article" @default.
• W4383375939 hasAuthorship W4383375939A5004000135 @default.
• W4383375939 hasAuthorship W4383375939A5012845876 @default.
• W4383375939 hasAuthorship W4383375939A5020398012 @default.
• W4383375939 hasAuthorship W4383375939A5023900529 @default.
• W4383375939 hasAuthorship W4383375939A5033684035 @default.
• W4383375939 hasAuthorship W4383375939A5037543576 @default.
• W4383375939 hasAuthorship W4383375939A5041780665 @default.
• W4383375939 hasAuthorship W4383375939A5053447705 @default.
• W4383375939 hasAuthorship W4383375939A5056967074 @default.
• W4383375939 hasAuthorship W4383375939A5069906360 @default.
• W4383375939 hasAuthorship W4383375939A5074695060 @default.
• W4383375939 hasAuthorship W4383375939A5082664098 @default.
• W4383375939 hasAuthorship W4383375939A5085530541 @default.
• W4383375939 hasConcept C104317684 @default.
• W4383375939 hasConcept C126322002 @default.
• W4383375939 hasConcept C127561419 @default.
• W4383375939 hasConcept C15490471 @default.
• W4383375939 hasConcept C169760540 @default.
• W4383375939 hasConcept C170493617 @default.
• W4383375939 hasConcept C185592680 @default.
• W4383375939 hasConcept C2775991916 @default.
• W4383375939 hasConcept C2777107010 @default.
• W4383375939 hasConcept C2777542381 @default.
• W4383375939 hasConcept C2779245659 @default.
• W4383375939 hasConcept C2780775167 @default.
• W4383375939 hasConcept C529278444 @default.
• W4383375939 hasConcept C55493867 @default.
• W4383375939 hasConcept C57074206 @default.
• W4383375939 hasConcept C62478195 @default.
• W4383375939 hasConcept C71924100 @default.
• W4383375939 hasConcept C86803240 @default.
• W4383375939 hasConcept C95444343 @default.
• W4383375939 hasConceptScore W4383375939C104317684 @default.
• W4383375939 hasConceptScore W4383375939C126322002 @default.
• W4383375939 hasConceptScore W4383375939C127561419 @default.
• W4383375939 hasConceptScore W4383375939C15490471 @default.
• W4383375939 hasConceptScore W4383375939C169760540 @default.
• W4383375939 hasConceptScore W4383375939C170493617 @default.
• W4383375939 hasConceptScore W4383375939C185592680 @default.
• W4383375939 hasConceptScore W4383375939C2775991916 @default.
• W4383375939 hasConceptScore W4383375939C2777107010 @default.
• W4383375939 hasConceptScore W4383375939C2777542381 @default.
• W4383375939 hasConceptScore W4383375939C2779245659 @default.
• W4383375939 hasConceptScore W4383375939C2780775167 @default.
• W4383375939 hasConceptScore W4383375939C529278444 @default.
• W4383375939 hasConceptScore W4383375939C55493867 @default.
• W4383375939 hasConceptScore W4383375939C57074206 @default.
• W4383375939 hasConceptScore W4383375939C62478195 @default.
• W4383375939 hasConceptScore W4383375939C71924100 @default.
• W4383375939 hasConceptScore W4383375939C86803240 @default.

• next