Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383376105> ?p ?o ?g. }
Showing items 1 to 63 of
63
with 100 items per page.
- W4383376105 abstract "Heart is composed of muscle cells called cardiomyocytes, including a specialized population, named pacemaker cells, that form the Cardiac Conduction System (CCS), responsible for generating the action potential dictating heart contractions. Failure of the CCS system leads to cardiac arrhythmias requiring complicated therapies and often surgical implantation of electrical pacemakers. However, recent research focusses on development of novel therapies using biological pacemakers aiming to substitute electrical devices. While most signalling pathways and transcription factors involved in the development of the pacemaker cells are known, the upstream regulatory networks need to be predicted through computer-based databases, mathematical modelling as well as functional testing of the regulatory elements in vivo, indicating the need for further research. Here we summarise the current knowledge about the vertebrate myocardial CCS system and development of the pacemaker cells and emphasise areas of future research to clarify the regulation of muscle pacemaker cells and ease development of biological therapies." @default.
- W4383376105 created "2023-07-07" @default.
- W4383376105 creator A5059135171 @default.
- W4383376105 creator A5074419157 @default.
- W4383376105 creator A5092414793 @default.
- W4383376105 date "2023-07-05" @default.
- W4383376105 modified "2023-10-16" @default.
- W4383376105 title "The development of specialised cardiac muscle cells within a vertebrate heart requires a specialised regulatory network" @default.
- W4383376105 doi "https://doi.org/10.20944/preprints202307.0335.v1" @default.
- W4383376105 hasPublicationYear "2023" @default.
- W4383376105 type Work @default.
- W4383376105 citedByCount "0" @default.
- W4383376105 crossrefType "posted-content" @default.
- W4383376105 hasAuthorship W4383376105A5059135171 @default.
- W4383376105 hasAuthorship W4383376105A5074419157 @default.
- W4383376105 hasAuthorship W4383376105A5092414793 @default.
- W4383376105 hasBestOaLocation W43833761051 @default.
- W4383376105 hasConcept C104317684 @default.
- W4383376105 hasConcept C104397207 @default.
- W4383376105 hasConcept C126322002 @default.
- W4383376105 hasConcept C169760540 @default.
- W4383376105 hasConcept C207200792 @default.
- W4383376105 hasConcept C2778198053 @default.
- W4383376105 hasConcept C2778642235 @default.
- W4383376105 hasConcept C2780040984 @default.
- W4383376105 hasConcept C2908647359 @default.
- W4383376105 hasConcept C54355233 @default.
- W4383376105 hasConcept C71924100 @default.
- W4383376105 hasConcept C86339819 @default.
- W4383376105 hasConcept C86803240 @default.
- W4383376105 hasConcept C95444343 @default.
- W4383376105 hasConcept C99454951 @default.
- W4383376105 hasConceptScore W4383376105C104317684 @default.
- W4383376105 hasConceptScore W4383376105C104397207 @default.
- W4383376105 hasConceptScore W4383376105C126322002 @default.
- W4383376105 hasConceptScore W4383376105C169760540 @default.
- W4383376105 hasConceptScore W4383376105C207200792 @default.
- W4383376105 hasConceptScore W4383376105C2778198053 @default.
- W4383376105 hasConceptScore W4383376105C2778642235 @default.
- W4383376105 hasConceptScore W4383376105C2780040984 @default.
- W4383376105 hasConceptScore W4383376105C2908647359 @default.
- W4383376105 hasConceptScore W4383376105C54355233 @default.
- W4383376105 hasConceptScore W4383376105C71924100 @default.
- W4383376105 hasConceptScore W4383376105C86339819 @default.
- W4383376105 hasConceptScore W4383376105C86803240 @default.
- W4383376105 hasConceptScore W4383376105C95444343 @default.
- W4383376105 hasConceptScore W4383376105C99454951 @default.
- W4383376105 hasLocation W43833761051 @default.
- W4383376105 hasOpenAccess W4383376105 @default.
- W4383376105 hasPrimaryLocation W43833761051 @default.
- W4383376105 hasRelatedWork W1998556240 @default.
- W4383376105 hasRelatedWork W2060604469 @default.
- W4383376105 hasRelatedWork W2082839753 @default.
- W4383376105 hasRelatedWork W2088458233 @default.
- W4383376105 hasRelatedWork W2159459254 @default.
- W4383376105 hasRelatedWork W262605308 @default.
- W4383376105 hasRelatedWork W4237806278 @default.
- W4383376105 hasRelatedWork W4247718175 @default.
- W4383376105 hasRelatedWork W4313444034 @default.
- W4383376105 hasRelatedWork W4367397467 @default.
- W4383376105 isParatext "false" @default.
- W4383376105 isRetracted "false" @default.
- W4383376105 workType "article" @default.