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- W4383376827 abstract "Infectious agents can pose a significant challenge in kidney transplantation, as they have the potential to cause direct infections in the transplanted kidney. These infections can lead to a decline in kidney function and reduce the longevity of the transplanted kidney. Common post-transplant allograft infections include bacterial pyelonephritis and the BK virus infection, while adenovirus, JC virus, and cytomegalovirus are less frequent but can also lead to significant allograft dysfunctions. The histopathological features of these infections are characterized by the infiltration of inflammatory cells in the kidney interstitial area and the presence of viral nuclear inclusions or cytopathic changes in the renal tubular epithelial cells. The confirmation of causative organisms can be achieved by immunohistochemical staining or the visualization of viral particles using electron microscopic examination. However, these methods typically require a longer turnaround time and are not readily available in developing countries, unlike standard hematoxylin-eosin staining. Notably, the differential diagnosis of interstitial inflammation in kidney allografts almost always includes T cell-mediated rejection, which has a different treatment approach than allograft infections. The aim of this review was to prompt clinicians to identify diverse pathological alterations as observed in kidney allograft biopsies, thereby facilitating further investigations and the management of suspected kidney allograft infections." @default.
- W4383376827 created "2023-07-07" @default.
- W4383376827 creator A5021536319 @default.
- W4383376827 creator A5083754428 @default.
- W4383376827 date "2023-07-05" @default.
- W4383376827 modified "2023-10-14" @default.
- W4383376827 title "Pathological Approach to Kidney Allograft Infection" @default.
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- W4383376827 doi "https://doi.org/10.3390/biomedicines11071902" @default.
- W4383376827 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37509541" @default.
- W4383376827 hasPublicationYear "2023" @default.
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