FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383481457> ?p ?o ?g. }

• W4383481457 endingPage "8" @default.
• W4383481457 startingPage "8" @default.
• W4383481457 abstract "Purpose: Systemic chloroquine/hydroxychloroquine (CQ/HCQ) can cause severe ocular side effects including bull's eye maculopathy (BEM). Recently, we reported higher quantitative autofluorescence (QAF) levels in patients with CQ/HCQ intake. Here, QAF in patients taking CQ/HCQ in a 1-year follow-up is reported. Methods: Fifty-eight patients currently or previously treated with CQ/HCQ (cumulative doses 94-2435 g) and 32 age- and sex-matched healthy subjects underwent multimodal retinal imaging (infrared, red free, fundus autofluorescence [FAF], QAF [488 nm], and spectral-domain optical coherence tomography (SD-OCT). For analysis, custom written FIJI plugins were used for image processing, multimodal image stacks assembling, and QAF calculation. Results: Thirty patients (28 without BEM and 2 with BEM, age range = 25–69 years) were followed up (370 ± 63 days). QAF values in patients taking CQ/HCQ showed a significant increase between baseline and follow-up examination: 282.0 ± 67.9 to 297.7 ± 70.0 (QAF a.u.), P = 0.002. An increase up to 10% was observed in the superior macular hemisphere. Eight individuals (including 1 patient with BEM) had a pronounced QAF increase of up to 25%. Compared to healthy controls, QAF levels in patients taking CQ/HCQ were significantly increased (P = 0.04). Conclusions: Our study confirms our previous finding of increased QAF in patients taking CQ/HCQ with a further significant QAF increase from baseline to follow-up. Whether pronounced QAF increase might predispose for rapid progression toward structural changes and BEM development is currently investigated in ongoing studies. Translational Relevance: In addition to standard screening tools during systemic CQ/HCQ treatment, QAF imaging might be useful in CQ/HCQ monitoring and could serve as a screening tool in the future." @default.
• W4383481457 created "2023-07-08" @default.
• W4383481457 creator A5016922490 @default.
• W4383481457 creator A5039894563 @default.
• W4383481457 creator A5041372859 @default.
• W4383481457 creator A5042475787 @default.
• W4383481457 creator A5042751397 @default.
• W4383481457 creator A5046475385 @default.
• W4383481457 creator A5048221982 @default.
• W4383481457 creator A5053825940 @default.
• W4383481457 creator A5066200684 @default.
• W4383481457 creator A5091335285 @default.
• W4383481457 date "2023-07-07" @default.
• W4383481457 modified "2023-10-14" @default.
• W4383481457 title "Quantitative Fundus Autofluorescence in Systemic Chloroquine/Hydroxychloroquine Therapy: One Year Follow-Up" @default.
• W4383481457 cites W1285309 @default.
• W4383481457 cites W1487688532 @default.
• W4383481457 cites W1521915926 @default.
• W4383481457 cites W1555307200 @default.
• W4383481457 cites W1599897764 @default.
• W4383481457 cites W1964290025 @default.
• W4383481457 cites W1964936470 @default.
• W4383481457 cites W1966502518 @default.
• W4383481457 cites W1982740394 @default.
• W4383481457 cites W1985283672 @default.
• W4383481457 cites W1992364186 @default.
• W4383481457 cites W1995818991 @default.
• W4383481457 cites W2006828037 @default.
• W4383481457 cites W2024585285 @default.
• W4383481457 cites W2025113750 @default.
• W4383481457 cites W2041876977 @default.
• W4383481457 cites W2059828017 @default.
• W4383481457 cites W2071235764 @default.
• W4383481457 cites W2074035096 @default.
• W4383481457 cites W2077598990 @default.
• W4383481457 cites W2092495589 @default.
• W4383481457 cites W2095161148 @default.
• W4383481457 cites W2106068866 @default.
• W4383481457 cites W2115959324 @default.
• W4383481457 cites W2123061158 @default.
• W4383481457 cites W2140071542 @default.
• W4383481457 cites W2151863617 @default.
• W4383481457 cites W2302013022 @default.
• W4383481457 cites W2329521208 @default.
• W4383481457 cites W2413657750 @default.
• W4383481457 cites W2471379186 @default.
• W4383481457 cites W2506061243 @default.
• W4383481457 cites W2515763619 @default.
• W4383481457 cites W2521846189 @default.
• W4383481457 cites W2559454315 @default.
• W4383481457 cites W2623332278 @default.
• W4383481457 cites W2914748450 @default.
• W4383481457 cites W2943909961 @default.
• W4383481457 cites W2954143561 @default.
• W4383481457 cites W2995104874 @default.
• W4383481457 cites W3000234413 @default.
• W4383481457 cites W3004709581 @default.
• W4383481457 cites W3039999777 @default.
• W4383481457 cites W3082705979 @default.
• W4383481457 cites W3088842731 @default.
• W4383481457 cites W3103455528 @default.
• W4383481457 cites W3126577985 @default.
• W4383481457 cites W3203460648 @default.
• W4383481457 cites W4225403131 @default.
• W4383481457 cites W4253960007 @default.
• W4383481457 cites W4282041149 @default.
• W4383481457 cites W4282591076 @default.
• W4383481457 cites W4285098667 @default.
• W4383481457 cites W45416255 @default.
• W4383481457 cites W99759542 @default.
• W4383481457 doi "https://doi.org/10.1167/tvst.12.7.8" @default.
• W4383481457 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37418250" @default.
• W4383481457 hasPublicationYear "2023" @default.
• W4383481457 type Work @default.
• W4383481457 citedByCount "0" @default.
• W4383481457 crossrefType "journal-article" @default.
• W4383481457 hasAuthorship W4383481457A5016922490 @default.
• W4383481457 hasAuthorship W4383481457A5039894563 @default.
• W4383481457 hasAuthorship W4383481457A5041372859 @default.
• W4383481457 hasAuthorship W4383481457A5042475787 @default.
• W4383481457 hasAuthorship W4383481457A5042751397 @default.
• W4383481457 hasAuthorship W4383481457A5046475385 @default.
• W4383481457 hasAuthorship W4383481457A5048221982 @default.
• W4383481457 hasAuthorship W4383481457A5053825940 @default.
• W4383481457 hasAuthorship W4383481457A5066200684 @default.
• W4383481457 hasAuthorship W4383481457A5091335285 @default.
• W4383481457 hasBestOaLocation W43834814571 @default.
• W4383481457 hasConcept C118487528 @default.
• W4383481457 hasConcept C121332964 @default.
• W4383481457 hasConcept C126322002 @default.
• W4383481457 hasConcept C134018914 @default.
• W4383481457 hasConcept C142724271 @default.
• W4383481457 hasConcept C179687394 @default.
• W4383481457 hasConcept C2777425658 @default.
• W4383481457 hasConcept C2778048844 @default.
• W4383481457 hasConcept C2778313320 @default.
• W4383481457 hasConcept C2779123688 @default.
• W4383481457 hasConcept C2779134260 @default.

• next