Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383482261> ?p ?o ?g. }
- W4383482261 endingPage "677" @default.
- W4383482261 startingPage "660" @default.
- W4383482261 abstract "The efficacy and safety of chemotherapy are two major challenges when it comes to treating ovarian cancer. The associated undesirable side effects of chemotherapy agents jeopardize the clinical intent and the efficiency of the therapy. Multiple studies have been published describing new developments and novel strategies utilizing the latest therapeutic and drug delivery technologies to address the efficacy and safety of chemotherapeutics in ovarian cancers. We have identified five novel technologies that are available and, if used, have the potential to mitigate the above-mentioned challenges. Nanocarriers in different forms (Nano-gel, Aptamer, peptide medicated formulations, Antibody-drug conjugation, surface charge, and nanovesicle technologies) are developed and available to be employed to target the cancerous tissue. These strategies are promising to improve clinical efficacy and reduce side effects. We have systematically searched and analyzed published data, as well as the authors intent for the described technology on each publication. We narrowed to 81 key articles and extracted their data to be discussed in this review. In summary, the selected articles investigated the pharmacokinetic properties of drugs combined with nanocarriers and found significant improvement in efficacy and safety by reducing the IC50 values and drug doses. These key papers described promising novel technologies in anti-cancer therapeutic approaches to enable sustained drug release and achieve prolonged drug performance near the tumor site or target tissue." @default.
- W4383482261 created "2023-07-08" @default.
- W4383482261 creator A5023868625 @default.
- W4383482261 creator A5029064434 @default.
- W4383482261 creator A5048852196 @default.
- W4383482261 creator A5090776764 @default.
- W4383482261 date "2023-07-19" @default.
- W4383482261 modified "2023-10-17" @default.
- W4383482261 title "A systematic review of emerging technologies to enhance the treatment of ovarian cancer" @default.
- W4383482261 cites W1661022711 @default.
- W4383482261 cites W1946170588 @default.
- W4383482261 cites W1989214948 @default.
- W4383482261 cites W1995765722 @default.
- W4383482261 cites W2006930441 @default.
- W4383482261 cites W2009281456 @default.
- W4383482261 cites W2017646924 @default.
- W4383482261 cites W2019910327 @default.
- W4383482261 cites W2024192600 @default.
- W4383482261 cites W2024912805 @default.
- W4383482261 cites W2029530232 @default.
- W4383482261 cites W2039122312 @default.
- W4383482261 cites W2055215223 @default.
- W4383482261 cites W2057768522 @default.
- W4383482261 cites W2064225223 @default.
- W4383482261 cites W2068624900 @default.
- W4383482261 cites W2070840273 @default.
- W4383482261 cites W2070912023 @default.
- W4383482261 cites W2077561265 @default.
- W4383482261 cites W2081269876 @default.
- W4383482261 cites W2082822107 @default.
- W4383482261 cites W2088594432 @default.
- W4383482261 cites W2103455702 @default.
- W4383482261 cites W2106074287 @default.
- W4383482261 cites W2124990167 @default.
- W4383482261 cites W2128568691 @default.
- W4383482261 cites W2129676318 @default.
- W4383482261 cites W2134187478 @default.
- W4383482261 cites W2139171257 @default.
- W4383482261 cites W2150458127 @default.
- W4383482261 cites W2152175544 @default.
- W4383482261 cites W2154812162 @default.
- W4383482261 cites W2161637076 @default.
- W4383482261 cites W2168804588 @default.
- W4383482261 cites W2171318838 @default.
- W4383482261 cites W2207474307 @default.
- W4383482261 cites W2213115246 @default.
- W4383482261 cites W2249509328 @default.
- W4383482261 cites W2265120954 @default.
- W4383482261 cites W2268043966 @default.
- W4383482261 cites W2285541813 @default.
- W4383482261 cites W2291172546 @default.
- W4383482261 cites W2317760145 @default.
- W4383482261 cites W2324583725 @default.
- W4383482261 cites W2331939950 @default.
- W4383482261 cites W2336093899 @default.
- W4383482261 cites W2337828948 @default.
- W4383482261 cites W2408480164 @default.
- W4383482261 cites W2416097600 @default.
- W4383482261 cites W2416932183 @default.
- W4383482261 cites W2551544186 @default.
- W4383482261 cites W2557482032 @default.
- W4383482261 cites W2566910113 @default.
- W4383482261 cites W2594404528 @default.
- W4383482261 cites W2737314905 @default.
- W4383482261 cites W2761665567 @default.
- W4383482261 cites W2762341360 @default.
- W4383482261 cites W2770498164 @default.
- W4383482261 cites W2782892489 @default.
- W4383482261 cites W2785103187 @default.
- W4383482261 cites W2790068157 @default.
- W4383482261 cites W2791343486 @default.
- W4383482261 cites W2799951892 @default.
- W4383482261 cites W2807764057 @default.
- W4383482261 cites W2810385438 @default.
- W4383482261 cites W2883715702 @default.
- W4383482261 cites W2884445981 @default.
- W4383482261 cites W2885226514 @default.
- W4383482261 cites W2887567490 @default.
- W4383482261 cites W2889494863 @default.
- W4383482261 cites W2890933028 @default.
- W4383482261 cites W2898791972 @default.
- W4383482261 cites W2901081518 @default.
- W4383482261 cites W2902383664 @default.
- W4383482261 cites W2905111869 @default.
- W4383482261 cites W2907444182 @default.
- W4383482261 cites W2909854152 @default.
- W4383482261 cites W2911411908 @default.
- W4383482261 cites W2912740901 @default.
- W4383482261 cites W2914661566 @default.
- W4383482261 cites W2919046613 @default.
- W4383482261 cites W2923441282 @default.
- W4383482261 cites W2927115307 @default.
- W4383482261 cites W2937047141 @default.
- W4383482261 cites W2985139644 @default.
- W4383482261 cites W2993138039 @default.
- W4383482261 cites W2999475046 @default.
- W4383482261 cites W3000036033 @default.
- W4383482261 cites W3008479944 @default.