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- W4383483069 endingPage "1907" @default.
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- W4383483069 abstract "In metazoans, living cells achieve capabilities beyond individual cell functionality by assembling into multicellular tissue structures. These higher-order structures represent dynamic, heterogeneous, and responsive systems that have evolved to regenerate and coordinate their actions over large distances. Recent advances in constructing micrometer-sized vesicles, or synthetic cells, now point to a future where construction of synthetic tissue can be pursued, a boon to pressing material needs in biomedical implants, drug delivery systems, adhesives, filters, and storage devices, among others. To fully realize the potential of synthetic tissue, inspiration has been and will continue to be drawn from new molecular findings on its natural counterpart. In this review, we describe advances in introducing tissue-scale features into synthetic cell assemblies. Beyond mere complexation, synthetic cells have been fashioned with a variety of natural and engineered molecular components that serve as initial steps toward morphological control and patterning, intercellular communication, replication, and responsiveness in synthetic tissue. Particular attention has been paid to the dynamics, spatial constraints, and mechanical strengths of interactions that drive the synthesis of this next-generation material, describing how multiple synthetic cells can act as one." @default.
- W4383483069 created "2023-07-08" @default.
- W4383483069 creator A5047319105 @default.
- W4383483069 creator A5064825362 @default.
- W4383483069 creator A5065692675 @default.
- W4383483069 date "2023-07-07" @default.
- W4383483069 modified "2023-10-18" @default.
- W4383483069 title "Engineering Tissue-Scale Properties with Synthetic Cells: Forging One from Many" @default.
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