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- W4383497640 endingPage "103404" @default.
- W4383497640 startingPage "103404" @default.
- W4383497640 abstract "Adoptive T cell therapy (ACT) is a fast developing, niche area of immunotherapy (IO), which is revolutionising the therapeutic landscape of solid tumour oncology, especially metastatic melanoma (MM). Identifying tumour antigens (TAs) as potential targets, the ACT response is mediated by either Tumour Infiltrating Lymphocytes (TILs) or genetically modified T cells with specific receptors - T cell receptors (TCRs) or chimeric antigen receptors (CARs) or more prospectively, natural killer (NK) cells. Clinical trials involving ACT in MM from 2006 to present have shown promising results. Yet it is not without its drawbacks which include significant auto-immune toxicity and need for pre-conditioning lymphodepletion. Although immune-modulation is underway using various combination therapies in the hope of enhancing efficacy and reducing toxicity. Our review article explores the role of ACT in MM, including the various modalities - their safety, efficacy, risks and their development in the trial and the real world setting." @default.
- W4383497640 created "2023-07-08" @default.
- W4383497640 creator A5002313676 @default.
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- W4383497640 creator A5084117294 @default.
- W4383497640 creator A5092420053 @default.
- W4383497640 date "2023-07-01" @default.
- W4383497640 modified "2023-10-18" @default.
- W4383497640 title "Advances in adoptive T-cell therapy for metastatic melanoma" @default.
- W4383497640 cites W1444462873 @default.
- W4383497640 cites W1491789131 @default.
- W4383497640 cites W1534815147 @default.
- W4383497640 cites W1867726658 @default.
- W4383497640 cites W1965480120 @default.
- W4383497640 cites W1965504034 @default.
- W4383497640 cites W1968566356 @default.
- W4383497640 cites W1979936799 @default.
- W4383497640 cites W1998566813 @default.
- W4383497640 cites W2006543081 @default.
- W4383497640 cites W2007665650 @default.
- W4383497640 cites W2010205433 @default.
- W4383497640 cites W2011458181 @default.
- W4383497640 cites W2016671320 @default.
- W4383497640 cites W2019164609 @default.
- W4383497640 cites W2031311358 @default.
- W4383497640 cites W2043904711 @default.
- W4383497640 cites W2047265596 @default.
- W4383497640 cites W2049119905 @default.
- W4383497640 cites W2052322683 @default.
- W4383497640 cites W2068173904 @default.
- W4383497640 cites W2069101649 @default.
- W4383497640 cites W2073606915 @default.
- W4383497640 cites W2087160901 @default.
- W4383497640 cites W2097175022 @default.
- W4383497640 cites W2099674544 @default.
- W4383497640 cites W2106285087 @default.
- W4383497640 cites W2107321795 @default.
- W4383497640 cites W2108583660 @default.
- W4383497640 cites W2111131433 @default.
- W4383497640 cites W2112121482 @default.
- W4383497640 cites W2113811237 @default.
- W4383497640 cites W2119207148 @default.
- W4383497640 cites W2124221877 @default.
- W4383497640 cites W2130473166 @default.
- W4383497640 cites W2138039929 @default.
- W4383497640 cites W2141121704 @default.
- W4383497640 cites W2141262236 @default.
- W4383497640 cites W2142081586 @default.
- W4383497640 cites W2145067668 @default.
- W4383497640 cites W2146494327 @default.
- W4383497640 cites W2146900850 @default.
- W4383497640 cites W2150065276 @default.
- W4383497640 cites W2150145041 @default.
- W4383497640 cites W2150817618 @default.
- W4383497640 cites W2153712501 @default.
- W4383497640 cites W2160766792 @default.
- W4383497640 cites W2164221986 @default.
- W4383497640 cites W2166662937 @default.
- W4383497640 cites W2169977177 @default.
- W4383497640 cites W2179056957 @default.
- W4383497640 cites W2181071874 @default.
- W4383497640 cites W2236938876 @default.
- W4383497640 cites W2253636300 @default.
- W4383497640 cites W2281137630 @default.
- W4383497640 cites W2345990767 @default.
- W4383497640 cites W2444015111 @default.
- W4383497640 cites W2473956396 @default.
- W4383497640 cites W2508710837 @default.
- W4383497640 cites W2540066182 @default.
- W4383497640 cites W2556349218 @default.
- W4383497640 cites W2573321206 @default.
- W4383497640 cites W2604996547 @default.
- W4383497640 cites W2608198193 @default.
- W4383497640 cites W2616234418 @default.
- W4383497640 cites W2619640871 @default.
- W4383497640 cites W2625835802 @default.
- W4383497640 cites W2743210207 @default.
- W4383497640 cites W2744685612 @default.
- W4383497640 cites W2783731426 @default.
- W4383497640 cites W2790290963 @default.
- W4383497640 cites W2791506170 @default.
- W4383497640 cites W2792588868 @default.
- W4383497640 cites W2806704237 @default.
- W4383497640 cites W2807110328 @default.
- W4383497640 cites W2808482831 @default.
- W4383497640 cites W2884769110 @default.
- W4383497640 cites W2886540861 @default.
- W4383497640 cites W2892787129 @default.
- W4383497640 cites W2900505005 @default.
- W4383497640 cites W2911882091 @default.
- W4383497640 cites W2919111067 @default.
- W4383497640 cites W2921627763 @default.
- W4383497640 cites W2924956524 @default.
- W4383497640 cites W2939487002 @default.
- W4383497640 cites W2948843630 @default.