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• W4383498283 abstract "This work is devoted to the effect of pressure on the structure of lamivudine by using Raman and infrared spectroscopy in diamond anvil cells. The results showed a transition from tetragonal crystal Form Ⅱ to an unknown Form Ⅲ' at approximately 1.26 GPa, followed by a transition from Form Ⅲ' to Form Ⅳ' at pressure of 7.23 GPa. The phase transitions were marked by unique profiles and pressure-dependent characteristic modes. Pressure-induced changes in structural symmetry led to conformational transition in lamivudine. Furthermore, there was a considerable conformational variation between A and D in lamivudine molecule to maintain structural balance. Spectroscopic measurements indicated that these pressure-induced changes were reversible below approximately 0.1 GPa." @default.
• W4383498283 created "2023-07-08" @default.
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• W4383498283 date "2023-11-01" @default.
• W4383498283 modified "2023-09-23" @default.
• W4383498283 title "High-pressure Polymorphism in Lamivudine" @default.
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• W4383498283 doi "https://doi.org/10.1016/j.molstruc.2023.136170" @default.
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