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• W4383499318 endingPage "136174" @default.
• W4383499318 startingPage "136174" @default.
• W4383499318 abstract "Herein, we established an environmentally benign green approach for the synthesis of new spiro-chromeno[2,3-d]pyrimidines. PEG-4000-OSO3H catalysed microwave-assisted multicomponent reaction of sesamol, isatin and barbituric acid enables us to produce spiro-chromeno[2,3-d]pyrimidines. This approach is notable for its eco-friendly polymer catalyst, rapid metal-free synthesis, easy workup, higher yield (88-97%), no need for column chromatographic purification and outstanding green credential parameters of the process. The use of harmless solvents, microwave process and reusability of reaction media made the present protocol sustainably effective from a green perspective. The molecular structure of 4j was confirmed by Single crystal XRD analysis and their DFT study was carried out. To gain insight into the molecule's geometry and physicochemical properties, quantum chemical density functional theory was employed at B3LYP/6-31G(d, p) basis set. Furthermore, all compounds were examined for antiproliferative activity against six solid human tumour cell lines. Compounds 4j and 4k exhibit excellent potency against T-47D (breast) and WiDr (colon) cell lines as compared to the standard drug cisplatin (CDDP). The most potent compound 4j, which exhibits GI50 values in the range 5.2–11 µM." @default.
• W4383499318 created "2023-07-08" @default.
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• W4383499318 date "2023-11-01" @default.
• W4383499318 modified "2023-10-17" @default.
• W4383499318 title "Insights into Microwave Assisted Synthesis of Spiro-chromeno[2,3-d]pyrimidines Using PEG-OSO3H Catalyst: DFT study and their antiproliferative activity" @default.
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• W4383499318 doi "https://doi.org/10.1016/j.molstruc.2023.136174" @default.
• W4383499318 hasPublicationYear "2023" @default.
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