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- W4383500880 endingPage "1172" @default.
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- W4383500880 abstract "Proton pump inhibitors (PPIs) reduce acid secretion in the stomach and rank as one of the most widely used acid-suppressing medicines globally. While PPIs are safe in the short-term, emerging evidence shows risks associated with long-term use. Current evidence on global PPI use is scarce. This systematic review aims to evaluate global PPI use in the general population.Ovid MEDLINE, Embase, and International Pharmaceutical Abstracts were systematically searched from inception to 31 March 2023 to identify observational studies on oral PPI use among individuals aged ≥ 18 years. PPI use was classified by demographics and medication factors (dose, duration, and PPI types). The absolute numbers of PPI users for each subcategory were summed and expressed as a percentage.The search identified data from 28 million PPI users in 23 countries from 65 articles. This review indicated that nearly one-quarter of adults use a PPI. Of those using PPIs, 63% were less than 65 years. 56% of PPI users were female, and White ethnicities accounted for 75% of users. Nearly two-thirds of users were on high doses (≥ defined daily dose (DDD)), 25% of users continued PPIs for > 1 year, and 28% of these continued for > 3 years.Given the widespread use PPIs and increasing concern regarding long-term use, this review provides a catalyst to support more rational use, particularly with unnecessary prolonged continuation. Clinicians should review PPI prescriptions regularly and deprescribe when there is no appropriate ongoing indication or evidence of benefit to reduce health harm and treatment cost." @default.
- W4383500880 created "2023-07-08" @default.
- W4383500880 creator A5046681247 @default.
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- W4383500880 creator A5082145716 @default.
- W4383500880 creator A5089913318 @default.
- W4383500880 date "2023-07-07" @default.
- W4383500880 modified "2023-10-17" @default.
- W4383500880 title "Proton pump inhibitor use: systematic review of global trends and practices" @default.
- W4383500880 cites W1596279001 @default.
- W4383500880 cites W1739143084 @default.
- W4383500880 cites W1791908438 @default.
- W4383500880 cites W1969059968 @default.
- W4383500880 cites W1970599732 @default.
- W4383500880 cites W1977163452 @default.
- W4383500880 cites W1987932579 @default.
- W4383500880 cites W1989031798 @default.
- W4383500880 cites W1997256477 @default.
- W4383500880 cites W1998240610 @default.
- W4383500880 cites W2000690476 @default.
- W4383500880 cites W2004984116 @default.
- W4383500880 cites W2012669252 @default.
- W4383500880 cites W2012943078 @default.
- W4383500880 cites W2013172082 @default.
- W4383500880 cites W2045569655 @default.
- W4383500880 cites W2049914520 @default.
- W4383500880 cites W2061515226 @default.
- W4383500880 cites W2078787982 @default.
- W4383500880 cites W2078802515 @default.
- W4383500880 cites W2080041075 @default.
- W4383500880 cites W2080750722 @default.
- W4383500880 cites W2102952461 @default.
- W4383500880 cites W2103790151 @default.
- W4383500880 cites W2130926472 @default.
- W4383500880 cites W2131921164 @default.
- W4383500880 cites W2134027168 @default.
- W4383500880 cites W2138843186 @default.
- W4383500880 cites W2151839099 @default.
- W4383500880 cites W2152169631 @default.
- W4383500880 cites W2158690779 @default.
- W4383500880 cites W2161822518 @default.
- W4383500880 cites W2276029718 @default.
- W4383500880 cites W2281035315 @default.
- W4383500880 cites W2291144080 @default.
- W4383500880 cites W2313279872 @default.
- W4383500880 cites W2335909636 @default.
- W4383500880 cites W2401431951 @default.
- W4383500880 cites W2409368746 @default.
- W4383500880 cites W2411350256 @default.
- W4383500880 cites W2476580486 @default.
- W4383500880 cites W2549868001 @default.
- W4383500880 cites W2555374952 @default.
- W4383500880 cites W2560669410 @default.
- W4383500880 cites W2567496133 @default.
- W4383500880 cites W2602830740 @default.
- W4383500880 cites W2734124754 @default.
- W4383500880 cites W2770930749 @default.
- W4383500880 cites W2790151975 @default.
- W4383500880 cites W2793897631 @default.
- W4383500880 cites W2805580957 @default.
- W4383500880 cites W2810784595 @default.
- W4383500880 cites W2887289383 @default.
- W4383500880 cites W2889390575 @default.
- W4383500880 cites W2891883151 @default.
- W4383500880 cites W2895840820 @default.
- W4383500880 cites W2899718652 @default.
- W4383500880 cites W2899757133 @default.
- W4383500880 cites W2906116370 @default.
- W4383500880 cites W2954553431 @default.
- W4383500880 cites W2956376384 @default.
- W4383500880 cites W2971668177 @default.
- W4383500880 cites W2974345919 @default.
- W4383500880 cites W2994704634 @default.
- W4383500880 cites W2995286804 @default.
- W4383500880 cites W3012229901 @default.
- W4383500880 cites W3023724839 @default.
- W4383500880 cites W3037251974 @default.
- W4383500880 cites W3080532135 @default.
- W4383500880 cites W3093713490 @default.
- W4383500880 cites W3105429857 @default.
- W4383500880 cites W3118615836 @default.
- W4383500880 cites W3154108648 @default.
- W4383500880 cites W3162715508 @default.
- W4383500880 cites W3183723440 @default.
- W4383500880 cites W3194499115 @default.
- W4383500880 cites W4200367488 @default.
- W4383500880 cites W4224323879 @default.
- W4383500880 cites W4283451422 @default.
- W4383500880 cites W4289549144 @default.
- W4383500880 cites W4313365069 @default.
- W4383500880 cites W4383500880 @default.
- W4383500880 doi "https://doi.org/10.1007/s00228-023-03534-z" @default.
- W4383500880 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37420019" @default.
- W4383500880 hasPublicationYear "2023" @default.
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