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- W4383532902 endingPage "104769" @default.
- W4383532902 startingPage "104769" @default.
- W4383532902 abstract "Immunosuppressive cytokines are a class of cytokines produced by immune cells and certain non-immune cells that have a suppressive effect on immune function. Currently known immunosuppressive cytokines include interleukin (IL)-10, transforming growth factor beta (TGF-β), IL-35, and IL-37. Although latest sequencing technologies have facilitated the identification of immunosuppressive cytokines in fish, IL-10 and TGF-β were the most well-known ones that have been widely studied and received continuous attention. Fish IL-10 and TGF-β have been identified as anti-inflammatory and immunosuppressive factors, acting on both innate and adaptive immune systems. However, unlike mammals, teleost fish underwent a third or fourth whole-genome duplication event, which significantly expanded the gene family associated with the cytokine signaling pathway, making the function and mechanism of these molecules need further investigation. In this review, we summarize the advances of studies on fish immunosuppressive cytokines IL-10 and TGF-β since their identification, mainly focusing on production, signaling transduction, and effects on the immunological function. This review aims to expand the understanding of the immunosuppressive cytokine network in fish." @default.
- W4383532902 created "2023-07-08" @default.
- W4383532902 creator A5010383775 @default.
- W4383532902 creator A5087811945 @default.
- W4383532902 creator A5089476014 @default.
- W4383532902 date "2023-10-01" @default.
- W4383532902 modified "2023-10-14" @default.
- W4383532902 title "Cytokine networks that suppress fish cellular immunity" @default.
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- W4383532902 doi "https://doi.org/10.1016/j.dci.2023.104769" @default.
- W4383532902 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37423553" @default.
- W4383532902 hasPublicationYear "2023" @default.
- W4383532902 type Work @default.