Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383533835> ?p ?o ?g. }
- W4383533835 abstract "Fatty acids and glucose are key biomolecules that share several commonalities including serving as energy substrates and as signaling molecules. Fatty acids can be synthesized endogenously from intermediates of glucose catabolism via de-novo lipogenesis. Bile acids are synthesized endogenously in the liver from the biologically important lipid molecule, cholesterol. Evidence abounds that fatty acids and bile acids play direct and indirect roles in systemic glucose homeostasis. The tight control of plasma glucose levels during postprandial and fasted states is principally mediated by two pancreatic hormones, insulin and glucagon. Here, we summarize experimental studies on the endocrine effects of fatty acids and bile acids, with emphasis on their ability to regulate the release of key hormones that regulate glucose metabolism. We categorize the heterogenous family of fatty acids into short chain fatty acids (SCFAs), unsaturated, and saturated fatty acids, and highlight that along with bile acids, these biomolecules regulate glucose homeostasis by serving as endogenous ligands for specific G-protein coupled receptors (GPCRs). Activation of these GPCRs affects the release of incretin hormones by enteroendocrine cells and/or the secretion of insulin, glucagon, and somatostatin by pancreatic islets, all of which regulate systemic glucose homeostasis. We deduce that signaling induced by fatty acids and bile acids is necessary to maintain euglycemia to prevent metabolic diseases such as type-2 diabetes and related metabolic disorders." @default.
- W4383533835 created "2023-07-08" @default.
- W4383533835 creator A5004075655 @default.
- W4383533835 creator A5018387405 @default.
- W4383533835 date "2023-07-07" @default.
- W4383533835 modified "2023-09-25" @default.
- W4383533835 title "GPCR-mediated effects of fatty acids and bile acids on glucose homeostasis" @default.
- W4383533835 cites W1076956034 @default.
- W4383533835 cites W1541434960 @default.
- W4383533835 cites W1555526329 @default.
- W4383533835 cites W1599065434 @default.
- W4383533835 cites W1603274157 @default.
- W4383533835 cites W179170519 @default.
- W4383533835 cites W1965796890 @default.
- W4383533835 cites W1970059084 @default.
- W4383533835 cites W1971639453 @default.
- W4383533835 cites W1979366725 @default.
- W4383533835 cites W1983228333 @default.
- W4383533835 cites W1983654296 @default.
- W4383533835 cites W1983822447 @default.
- W4383533835 cites W2015790086 @default.
- W4383533835 cites W2017362076 @default.
- W4383533835 cites W2019925176 @default.
- W4383533835 cites W2020275122 @default.
- W4383533835 cites W2021651701 @default.
- W4383533835 cites W2024148046 @default.
- W4383533835 cites W2031069848 @default.
- W4383533835 cites W2032767323 @default.
- W4383533835 cites W2034766774 @default.
- W4383533835 cites W2035391709 @default.
- W4383533835 cites W2035421462 @default.
- W4383533835 cites W2037921130 @default.
- W4383533835 cites W2038437736 @default.
- W4383533835 cites W2046315492 @default.
- W4383533835 cites W2053196978 @default.
- W4383533835 cites W2057039181 @default.
- W4383533835 cites W2059351011 @default.
- W4383533835 cites W2063913905 @default.
- W4383533835 cites W2066196011 @default.
- W4383533835 cites W2067689880 @default.
- W4383533835 cites W2076511407 @default.
- W4383533835 cites W2077936393 @default.
- W4383533835 cites W2080483538 @default.
- W4383533835 cites W2081271380 @default.
- W4383533835 cites W2088773716 @default.
- W4383533835 cites W2088986234 @default.
- W4383533835 cites W2089608246 @default.
- W4383533835 cites W2090360729 @default.
- W4383533835 cites W2092834109 @default.
- W4383533835 cites W2096418655 @default.
- W4383533835 cites W2097503559 @default.
- W4383533835 cites W2100958442 @default.
- W4383533835 cites W2101096393 @default.
- W4383533835 cites W2105604211 @default.
- W4383533835 cites W2108878645 @default.
- W4383533835 cites W2113961306 @default.
- W4383533835 cites W2122905319 @default.
- W4383533835 cites W2131094572 @default.
- W4383533835 cites W2132033020 @default.
- W4383533835 cites W2144509989 @default.
- W4383533835 cites W2144701449 @default.
- W4383533835 cites W2150807020 @default.
- W4383533835 cites W2151845029 @default.
- W4383533835 cites W2153813367 @default.
- W4383533835 cites W2155841407 @default.
- W4383533835 cites W2168842536 @default.
- W4383533835 cites W2181744396 @default.
- W4383533835 cites W2182287566 @default.
- W4383533835 cites W2186068515 @default.
- W4383533835 cites W2199129476 @default.
- W4383533835 cites W2233148118 @default.
- W4383533835 cites W2251931744 @default.
- W4383533835 cites W2279049687 @default.
- W4383533835 cites W2286791870 @default.
- W4383533835 cites W2288938787 @default.
- W4383533835 cites W2443601239 @default.
- W4383533835 cites W2518316517 @default.
- W4383533835 cites W2523369352 @default.
- W4383533835 cites W2523620612 @default.
- W4383533835 cites W2537222257 @default.
- W4383533835 cites W2593374976 @default.
- W4383533835 cites W2604117018 @default.
- W4383533835 cites W2604209550 @default.
- W4383533835 cites W2606156515 @default.
- W4383533835 cites W2608737760 @default.
- W4383533835 cites W2612631436 @default.
- W4383533835 cites W2773465543 @default.
- W4383533835 cites W2781627604 @default.
- W4383533835 cites W2782382515 @default.
- W4383533835 cites W2783048272 @default.
- W4383533835 cites W2809791747 @default.
- W4383533835 cites W2885588864 @default.
- W4383533835 cites W2892141974 @default.
- W4383533835 cites W2897735760 @default.
- W4383533835 cites W2899339394 @default.
- W4383533835 cites W2914141586 @default.
- W4383533835 cites W2937428609 @default.
- W4383533835 cites W2940492200 @default.
- W4383533835 cites W2946372752 @default.
- W4383533835 cites W2952911704 @default.