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- W4383534352 abstract "B cells play essential roles in immunity, mainly through the production of high affinity plasma cells (PCs) and memory B (Bmem) cells. The affinity maturation and differentiation of B cells rely on the integration of B-cell receptor (BCR) intrinsic and extrinsic signals provided by antigen binding and the microenvironment, respectively. In recent years, tumor infiltrating B (TIL-B) cells and PCs (TIL-PCs) have been revealed as important players in antitumor responses in human cancers, but their interplay and dynamics remain largely unknown. In lymphoid organs, B-cell responses involve both germinal center (GC)-dependent and GC-independent pathways for Bmem cell and PC production. Affinity maturation of BCR repertoires occurs in GC reactions with specific spatiotemporal dynamics of signal integration by B cells. In general, the reactivation of high-affinity Bmem cells by antigens triggers GC-independent production of large numbers of PC without BCR rediversification. Understanding B-cell dynamics in immune responses requires the integration of multiple tools and readouts such as single-cell phenotyping and RNA-seq, in situ analyses, BCR repertoire analysis, BCR specificity and affinity assays, and functional tests. Here, we review how those tools have recently been applied to study TIL-B cells and TIL-PC in different types of solid tumors. We assessed the published evidence for different models of TIL-B-cell dynamics involving GC-dependent or GC-independent local responses and the resulting production of antigen-specific PCs. Altogether, we highlight the need for more integrative B-cell immunology studies to rationally investigate TIL-B cells as a leverage for antitumor therapies." @default.
- W4383534352 created "2023-07-08" @default.
- W4383534352 creator A5015554426 @default.
- W4383534352 creator A5023634131 @default.
- W4383534352 creator A5090256483 @default.
- W4383534352 creator A5092422507 @default.
- W4383534352 date "2023-07-07" @default.
- W4383534352 modified "2023-10-14" @default.
- W4383534352 title "Germinal center-dependent and -independent immune responses of tumor-infiltrating B cells in human cancers" @default.
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- W4383534352 doi "https://doi.org/10.1038/s41423-023-01060-7" @default.
- W4383534352 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37419983" @default.
- W4383534352 hasPublicationYear "2023" @default.
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