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• W4383534650 abstract "IQGAP1 is a multi-functional scaffold protein. However, its role in B cell development and function is not known. Here, we demonstrate Iqgap1mice contained significantly increased numbers of B220+ B, B220+IgM pro/pre-B, and B220+IgM+ immature-B cells in the bone marrow. Here, we show IQGAP1 as the essential scaffold that regulates early B cell development and function. Iqgap1mice contained significantly increased numbers of B220+ B, B220+IgM pro/pre-B, and B220+IgM+ immature-B cells in the bone marrow. New-forming and follicular B cell numbers were increased, while the marginal zone B cell numbers were significantly reduced in the spleen of the Iqgap1mice. Lack of IQGAP1 reduced T-dependent and T-independent humoral responses. Mechanistically, the lack of IQGAP1 considerably decreased the phosphorylation of Mek1/2, Erk1/2, and Jnk1/2. B cells from Iqgap1mice failed to suppress IL-7R-mediated activation of Stat5a/b, an essential step for cell-cycle exit and initiate light-chain recombination, leading to a reduction in RS rearrangement frequency. Lack of IQGAP1 resulted in a significant reduction of IRF4 and IRF8 in BM B cells. Our study provides the first evidence that IQGAP1-based signalosome is essential for the development and functions of B cells." @default.
• W4383534650 created "2023-07-08" @default.
• W4383534650 creator A5001337472 @default.
• W4383534650 creator A5071342682 @default.
• W4383534650 date "2023-07-07" @default.
• W4383534650 modified "2023-10-16" @default.
• W4383534650 title "IQGAP1 Promotes Early B Cell Development, Is Essential for the Development of Marginal Zone (MZ) B Cells, and Is Critical for Both T-Dependent and T-Independent Antibody Responses" @default.
• W4383534650 doi "https://doi.org/10.20944/preprints202307.0442.v1" @default.
• W4383534650 hasPublicationYear "2023" @default.
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