Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383536344> ?p ?o ?g. }
- W4383536344 endingPage "972" @default.
- W4383536344 startingPage "972" @default.
- W4383536344 abstract "Big conductance calcium-activated (BK) channel openers can inhibit pathologically driven neural hyperactivity to control symptoms via hyperpolarizing signals to limit neural excitability. We hypothesized that BK channel openers would be neuroprotective during neuroinflammatory, autoimmune disease. The neurodegenerative disease was induced in a mouse experimental autoimmune encephalomyelitis model with translational value to detect neuroprotection in multiple sclerosis. Following the treatment with the BK channel openers, BMS-204253 and VSN16R, neuroprotection was assessed using subjective and objective clinical outcomes and by quantitating spinal nerve content. Treatment with BMS-204253 and VSN16R did not inhibit the development of relapsing autoimmunity, consistent with minimal channel expression via immune cells, nor did it change leukocyte levels in rodents or humans. However, it inhibited the accumulation of nerve loss and disability as a consequence of autoimmunity. Therefore, in addition to symptom control, BK channel openers have the potential to save nerves from excitotoxic damage and could be useful as either stand-alone neuroprotective agents or as add-ons to current disease-modifying treatments that block relapsing MS but do not have any direct neuroprotective activity." @default.
- W4383536344 created "2023-07-08" @default.
- W4383536344 creator A5015754502 @default.
- W4383536344 creator A5016912802 @default.
- W4383536344 creator A5026824813 @default.
- W4383536344 creator A5063757411 @default.
- W4383536344 creator A5086639238 @default.
- W4383536344 date "2023-07-07" @default.
- W4383536344 modified "2023-10-18" @default.
- W4383536344 title "Neuroprotection in an Experimental Model of Multiple Sclerosis via Opening of Big Conductance, Calcium-Activated Potassium Channels" @default.
- W4383536344 cites W1446040360 @default.
- W4383536344 cites W1631419451 @default.
- W4383536344 cites W1957911250 @default.
- W4383536344 cites W1963939589 @default.
- W4383536344 cites W1983528380 @default.
- W4383536344 cites W1984949427 @default.
- W4383536344 cites W1988771698 @default.
- W4383536344 cites W1993563590 @default.
- W4383536344 cites W2007833740 @default.
- W4383536344 cites W2010252923 @default.
- W4383536344 cites W2012034410 @default.
- W4383536344 cites W2016763372 @default.
- W4383536344 cites W2048809264 @default.
- W4383536344 cites W2052994550 @default.
- W4383536344 cites W2054275187 @default.
- W4383536344 cites W2057306894 @default.
- W4383536344 cites W2060529596 @default.
- W4383536344 cites W2065189003 @default.
- W4383536344 cites W2068648104 @default.
- W4383536344 cites W2069232604 @default.
- W4383536344 cites W2070069129 @default.
- W4383536344 cites W2075388863 @default.
- W4383536344 cites W2079391496 @default.
- W4383536344 cites W2080005922 @default.
- W4383536344 cites W2098008723 @default.
- W4383536344 cites W2104613203 @default.
- W4383536344 cites W2106876831 @default.
- W4383536344 cites W2109108939 @default.
- W4383536344 cites W2116144264 @default.
- W4383536344 cites W2122083429 @default.
- W4383536344 cites W2122935607 @default.
- W4383536344 cites W2123879187 @default.
- W4383536344 cites W2135123671 @default.
- W4383536344 cites W2142496715 @default.
- W4383536344 cites W2151572058 @default.
- W4383536344 cites W2153372855 @default.
- W4383536344 cites W2158699108 @default.
- W4383536344 cites W2164683872 @default.
- W4383536344 cites W2205409324 @default.
- W4383536344 cites W2270933859 @default.
- W4383536344 cites W2465886212 @default.
- W4383536344 cites W2588643061 @default.
- W4383536344 cites W2597054145 @default.
- W4383536344 cites W2597981375 @default.
- W4383536344 cites W2604213817 @default.
- W4383536344 cites W2731853540 @default.
- W4383536344 cites W2896014118 @default.
- W4383536344 cites W3012569500 @default.
- W4383536344 cites W3127539648 @default.
- W4383536344 cites W3174869254 @default.
- W4383536344 cites W3187769147 @default.
- W4383536344 cites W3212182683 @default.
- W4383536344 cites W4285726284 @default.
- W4383536344 cites W4295709314 @default.
- W4383536344 cites W4304823016 @default.
- W4383536344 cites W4309922678 @default.
- W4383536344 cites W4377288030 @default.
- W4383536344 cites W61928364 @default.
- W4383536344 doi "https://doi.org/10.3390/ph16070972" @default.
- W4383536344 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37513884" @default.
- W4383536344 hasPublicationYear "2023" @default.
- W4383536344 type Work @default.
- W4383536344 citedByCount "0" @default.
- W4383536344 crossrefType "journal-article" @default.
- W4383536344 hasAuthorship W4383536344A5015754502 @default.
- W4383536344 hasAuthorship W4383536344A5016912802 @default.
- W4383536344 hasAuthorship W4383536344A5026824813 @default.
- W4383536344 hasAuthorship W4383536344A5063757411 @default.
- W4383536344 hasAuthorship W4383536344A5086639238 @default.
- W4383536344 hasBestOaLocation W43835363441 @default.
- W4383536344 hasConcept C126322002 @default.
- W4383536344 hasConcept C169760540 @default.
- W4383536344 hasConcept C203014093 @default.
- W4383536344 hasConcept C25498285 @default.
- W4383536344 hasConcept C2778486448 @default.
- W4383536344 hasConcept C2780130043 @default.
- W4383536344 hasConcept C2780640218 @default.
- W4383536344 hasConcept C61144316 @default.
- W4383536344 hasConcept C71924100 @default.
- W4383536344 hasConcept C83743174 @default.
- W4383536344 hasConcept C86803240 @default.
- W4383536344 hasConcept C8891405 @default.
- W4383536344 hasConcept C98274493 @default.
- W4383536344 hasConceptScore W4383536344C126322002 @default.
- W4383536344 hasConceptScore W4383536344C169760540 @default.
- W4383536344 hasConceptScore W4383536344C203014093 @default.
- W4383536344 hasConceptScore W4383536344C25498285 @default.
- W4383536344 hasConceptScore W4383536344C2778486448 @default.