Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383551330> ?p ?o ?g. }
- W4383551330 endingPage "11148" @default.
- W4383551330 startingPage "11148" @default.
- W4383551330 abstract "Intracellular environment includes proteins, sugars, and nucleic acids interacting in restricted media. In the cytoplasm, the excluded volume effect takes up to 40% of the volume available for occupation by macromolecules. In this work, we tested several approaches modeling crowded solutions for protein diffusion. We experimentally showed how the protein diffusion deviates from conventional Brownian motion in artificial conditions modeling the alteration of medium viscosity and rigid spatial obstacles. The studied tracer proteins were globular bovine serum albumin and intrinsically disordered α-casein. Using the pulsed field gradient NMR, we investigated the translational diffusion of protein probes of different structures in homogeneous (glycerol) and heterogeneous (PEG 300/PEG 6000/PEG 40,000) solutions as a function of crowder concentration. Our results showed fundamentally different effects of homogeneous and heterogeneous crowded environments on protein self-diffusion. In addition, the applied “tracer on lattice” model showed that smaller crowding obstacles (PEG 300 and PEG 6000) create a dense net of restrictions noticeably hindering diffusing protein probes, whereas the large-sized PEG 40,000 creates a “less restricted” environment for the diffusive motion of protein molecules." @default.
- W4383551330 created "2023-07-08" @default.
- W4383551330 creator A5015087291 @default.
- W4383551330 creator A5052026115 @default.
- W4383551330 creator A5053165802 @default.
- W4383551330 date "2023-07-06" @default.
- W4383551330 modified "2023-09-26" @default.
- W4383551330 title "Effects of Homogeneous and Heterogeneous Crowding on Translational Diffusion of Rigid Bovine Serum Albumin and Disordered Alfa-Casein" @default.
- W4383551330 cites W1770591670 @default.
- W4383551330 cites W1965950722 @default.
- W4383551330 cites W1966878121 @default.
- W4383551330 cites W1972280445 @default.
- W4383551330 cites W1977360274 @default.
- W4383551330 cites W1979219785 @default.
- W4383551330 cites W1980705692 @default.
- W4383551330 cites W1981539237 @default.
- W4383551330 cites W1981608015 @default.
- W4383551330 cites W1983903436 @default.
- W4383551330 cites W1985687234 @default.
- W4383551330 cites W1988377264 @default.
- W4383551330 cites W1990728218 @default.
- W4383551330 cites W1992513829 @default.
- W4383551330 cites W1992769555 @default.
- W4383551330 cites W1996864702 @default.
- W4383551330 cites W1998036936 @default.
- W4383551330 cites W2003853977 @default.
- W4383551330 cites W2004984389 @default.
- W4383551330 cites W2005202913 @default.
- W4383551330 cites W2006514416 @default.
- W4383551330 cites W2008935619 @default.
- W4383551330 cites W2012500478 @default.
- W4383551330 cites W2019679930 @default.
- W4383551330 cites W2021331553 @default.
- W4383551330 cites W2024064076 @default.
- W4383551330 cites W2025999562 @default.
- W4383551330 cites W2037477418 @default.
- W4383551330 cites W2038936757 @default.
- W4383551330 cites W2043273650 @default.
- W4383551330 cites W2045400677 @default.
- W4383551330 cites W2048745583 @default.
- W4383551330 cites W2052582745 @default.
- W4383551330 cites W2054361320 @default.
- W4383551330 cites W2056818925 @default.
- W4383551330 cites W2057923125 @default.
- W4383551330 cites W2059172969 @default.
- W4383551330 cites W2062225510 @default.
- W4383551330 cites W2067680762 @default.
- W4383551330 cites W2067790068 @default.
- W4383551330 cites W2072616202 @default.
- W4383551330 cites W2072637588 @default.
- W4383551330 cites W2080019243 @default.
- W4383551330 cites W2084097498 @default.
- W4383551330 cites W2085519055 @default.
- W4383551330 cites W2087707502 @default.
- W4383551330 cites W2088858313 @default.
- W4383551330 cites W2104962501 @default.
- W4383551330 cites W2111271983 @default.
- W4383551330 cites W2111739264 @default.
- W4383551330 cites W2116555198 @default.
- W4383551330 cites W2123254545 @default.
- W4383551330 cites W2138380905 @default.
- W4383551330 cites W2150766477 @default.
- W4383551330 cites W2157143879 @default.
- W4383551330 cites W2166582022 @default.
- W4383551330 cites W2168769318 @default.
- W4383551330 cites W2169113904 @default.
- W4383551330 cites W2218000956 @default.
- W4383551330 cites W2226243838 @default.
- W4383551330 cites W2254075880 @default.
- W4383551330 cites W2277438596 @default.
- W4383551330 cites W2283931742 @default.
- W4383551330 cites W2299214998 @default.
- W4383551330 cites W2315787946 @default.
- W4383551330 cites W2318474524 @default.
- W4383551330 cites W2322720143 @default.
- W4383551330 cites W2329601201 @default.
- W4383551330 cites W2344452957 @default.
- W4383551330 cites W2409577334 @default.
- W4383551330 cites W2417648046 @default.
- W4383551330 cites W2485048396 @default.
- W4383551330 cites W2520294492 @default.
- W4383551330 cites W2550153087 @default.
- W4383551330 cites W2568691143 @default.
- W4383551330 cites W2599195848 @default.
- W4383551330 cites W2615134124 @default.
- W4383551330 cites W2759904048 @default.
- W4383551330 cites W2767630342 @default.
- W4383551330 cites W2774087096 @default.
- W4383551330 cites W2793437003 @default.
- W4383551330 cites W2802490864 @default.
- W4383551330 cites W2809890174 @default.
- W4383551330 cites W2886143754 @default.
- W4383551330 cites W2889188325 @default.
- W4383551330 cites W2892691639 @default.
- W4383551330 cites W2914323840 @default.
- W4383551330 cites W2939052792 @default.
- W4383551330 cites W2944266750 @default.
- W4383551330 cites W2970696575 @default.