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W4383553764 abstract "<p>Comparison of Type I IFN gene expression in different CAR-T engineering approaches. (A-F) show volcano plots and a heatmap of gene expression in engineered CAR T-cells, with type I IFN genes highlighted in blue. These data represent different CAR-T engineering approaches, including: BRG1/BRM-associated factors (BAF) complex, Gata3, INO80 complex knockout (PMID35750052), BATF overexpression (PMID34282330), 4-1BB- versus CD28-based GD2 CAR activity (PMID 25939063) and 1xx CD19 CAR T-cells (GSE121226). These plots allow for a comparison of the levels of type I IFN gene expression in each of these different CAR-T engineering methods.</p>" @default.
W4383553764 created "2023-07-08" @default.
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W4383553764 date "2023-07-07" @default.
W4383553764 modified "2023-10-18" @default.
W4383553764 title "Figure S8 from Type I Interferon Signaling via the EGR2 Transcriptional Regulator Potentiates CAR T Cell–Intrinsic Dysfunction" @default.
W4383553764 doi "https://doi.org/10.1158/2159-8290.23641371" @default.
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