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- W4383554477 abstract "Hypoxia is encountered frequently in the ICU as a result of a wide range of pathologic characteristics. The oxygen-hemoglobin dissociation curve describes hemoglobin's affinity for a given Po2 and factors affecting uptake and offload. Research in manipulating this relationship between hemoglobin and oxygen is sparing. Voxelotor is a hemoglobin oxygen-affinity modulator that is approved by the US Food and Drug Association for use in the management of sickle cell disease. We present two patients without sickle cell disease who underwent treatment with this novel agent to assist with chronic hypoxia and weaning of mechanical support." @default.
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- W4383554477 date "2023-07-01" @default.
- W4383554477 modified "2023-10-18" @default.
- W4383554477 title "Voxelotor as a Treatment of Persistent Hypoxia in the ICU" @default.
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- W4383554477 doi "https://doi.org/10.1016/j.chest.2023.01.036" @default.
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