FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W4383554910> ?p ?o ?g. }

• W4383554910 abstract "Background: Centrosomal Protein 55 (CEP55) was initially described as a main participant in the final stage of cytokinesis. Further research identified CEP55 as a cancer-testis antigen (CTA) that is aberrantly expressed in different malignancies and a cancer vaccination candidate. The current study aimed to disclose the complete expression of CEP55, its effect on various malignancy prognoses, and its role in the tumor microenvironment. Methods: Transcriptional information regarding tumor and normal tissues, as well as externally validated and protein expression data were gathered from the Cancer Genome Atlas, Genotype-Tissue Expression project, Gene Expression Omnibus, and Human Protein Atlas. We examined the effect of CEP55 on tumor prognosis using Kaplan-Meier (KM) and univariate Cox regression analyses. In addition, we investigated the connections between CEP55 expression and hallmark cancer pathways, immune cell infiltration, and immune regulator expression across malignancies. We constructed and validated a CEP55-related risk model for hepatocellular carcinoma (HCC) and explored the correlations between CEP55 expression and HCC molecular subtypes. Finally, we investigated putative small-molecule drugs targeting CEP55 using a connectivity map (CMap) database and validated them using molecular docking analysis. Findings: CEP55 was aberrantly expressed in most cancers and revealed a prognostic value for several malignancies. Cancers with high CEP55 expression showed significantly enhanced cell cycle, proliferation, and immune-related pathways. For most malignancies, elevated CEP55 expression was associated with the infiltration of myeloid-derived suppressor cells (MDSCs) and Th2 cells. In addition, CEP55 expression was linked to immunomodulators and the potential prediction of immune checkpoint inhibitor (ICI) responses, and strongly associated with distinct molecular HCC subtypes, whereby the CEP55-based nomogram performed well in predicting short- and long-term HCC survival. Finally, we used connectivity map (CMap) and molecular docking analyses to discover three candidate small-molecule drugs that could directly bind to CEP55. Conclusion: CEP55 affected the occurrence and development of various cancers and possibly the regulation of the tumor immune microenvironment. Our findings suggest that CEP55 is a potential biomarker for prognosis and a powerful biomarker for ICI efficacy prediction." @default.
• W4383554910 created "2023-07-08" @default.
• W4383554910 creator A5021782944 @default.
• W4383554910 creator A5036418759 @default.
• W4383554910 creator A5050723744 @default.
• W4383554910 creator A5052801908 @default.
• W4383554910 creator A5057528778 @default.
• W4383554910 creator A5062236580 @default.
• W4383554910 creator A5085142676 @default.
• W4383554910 creator A5091074428 @default.
• W4383554910 creator A5092424229 @default.
• W4383554910 date "2023-07-07" @default.
• W4383554910 modified "2023-10-12" @default.
• W4383554910 title "Cancer-testis antigen CEP55 serves as a prognostic biomarker and is correlated with immune infiltration and immunotherapy efficacy in pan-cancer" @default.
• W4383554910 cites W1542666708 @default.
• W4383554910 cites W1986977732 @default.
• W4383554910 cites W1988038318 @default.
• W4383554910 cites W2002246796 @default.
• W4383554910 cites W2003429634 @default.
• W4383554910 cites W2004150448 @default.
• W4383554910 cites W2012034410 @default.
• W4383554910 cites W2023815439 @default.
• W4383554910 cites W2025071904 @default.
• W4383554910 cites W2032153614 @default.
• W4383554910 cites W2035618305 @default.
• W4383554910 cites W2047246023 @default.
• W4383554910 cites W2071065486 @default.
• W4383554910 cites W2074403409 @default.
• W4383554910 cites W2082566384 @default.
• W4383554910 cites W2089566302 @default.
• W4383554910 cites W2092736758 @default.
• W4383554910 cites W2098334616 @default.
• W4383554910 cites W2099789788 @default.
• W4383554910 cites W2103543394 @default.
• W4383554910 cites W2112670248 @default.
• W4383554910 cites W2114843025 @default.
• W4383554910 cites W2116562412 @default.
• W4383554910 cites W2121604817 @default.
• W4383554910 cites W2130430382 @default.
• W4383554910 cites W2136415416 @default.
• W4383554910 cites W2146512944 @default.
• W4383554910 cites W2149441684 @default.
• W4383554910 cites W2159478099 @default.
• W4383554910 cites W2172466148 @default.
• W4383554910 cites W2394893668 @default.
• W4383554910 cites W2419791212 @default.
• W4383554910 cites W2527404829 @default.
• W4383554910 cites W2587048937 @default.
• W4383554910 cites W2607211817 @default.
• W4383554910 cites W2609882252 @default.
• W4383554910 cites W2765224588 @default.
• W4383554910 cites W2796207838 @default.
• W4383554910 cites W2799849968 @default.
• W4383554910 cites W2826306828 @default.
• W4383554910 cites W2886288610 @default.
• W4383554910 cites W2886942508 @default.
• W4383554910 cites W2902230100 @default.
• W4383554910 cites W2907001574 @default.
• W4383554910 cites W2935893374 @default.
• W4383554910 cites W2999444600 @default.
• W4383554910 cites W3014701180 @default.
• W4383554910 cites W3016296419 @default.
• W4383554910 cites W3017447724 @default.
• W4383554910 cites W3027286012 @default.
• W4383554910 cites W3027599578 @default.
• W4383554910 cites W3042430778 @default.
• W4383554910 cites W3096818982 @default.
• W4383554910 cites W3098280565 @default.
• W4383554910 cites W3112745999 @default.
• W4383554910 cites W3117722827 @default.
• W4383554910 cites W3128646645 @default.
• W4383554910 cites W3158086066 @default.
• W4383554910 cites W3162224241 @default.
• W4383554910 cites W4200039125 @default.
• W4383554910 cites W4206127585 @default.
• W4383554910 cites W4225508609 @default.
• W4383554910 cites W4232620598 @default.
• W4383554910 cites W4315754639 @default.
• W4383554910 doi "https://doi.org/10.3389/fmolb.2023.1198557" @default.
• W4383554910 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/37484531" @default.
• W4383554910 hasPublicationYear "2023" @default.
• W4383554910 type Work @default.
• W4383554910 citedByCount "0" @default.
• W4383554910 crossrefType "journal-article" @default.
• W4383554910 hasAuthorship W4383554910A5021782944 @default.
• W4383554910 hasAuthorship W4383554910A5036418759 @default.
• W4383554910 hasAuthorship W4383554910A5050723744 @default.
• W4383554910 hasAuthorship W4383554910A5052801908 @default.
• W4383554910 hasAuthorship W4383554910A5057528778 @default.
• W4383554910 hasAuthorship W4383554910A5062236580 @default.
• W4383554910 hasAuthorship W4383554910A5085142676 @default.
• W4383554910 hasAuthorship W4383554910A5091074428 @default.
• W4383554910 hasAuthorship W4383554910A5092424229 @default.
• W4383554910 hasBestOaLocation W43835549101 @default.
• W4383554910 hasConcept C121608353 @default.
• W4383554910 hasConcept C203014093 @default.
• W4383554910 hasConcept C2777701055 @default.
• W4383554910 hasConcept C2780674031 @default.
• W4383554910 hasConcept C2780851360 @default.
• W4383554910 hasConcept C502942594 @default.

• next